The Effect of Diabetes Mellitus on Cardiac Remodeling and Overall Clinical Outcomes in Patients With Acute Myocardial Infarction: A Single-Center Retrospective Study in Saudi Arabia.

Autor:	Albakistani AA; College of Medicine, King Abdullah International Medical Research Center, Jeddah, SAU.; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU., Alqerafi AA; College of Medicine, King Abdullah International Medical Research Center, Jeddah, SAU.; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU., Marghalani YO; College of Medicine, King Abdullah International Medical Research Center, Jeddah, SAU.; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU., Alasmari RS; College of Medicine, King Abdullah International Medical Research Center, Jeddah, SAU.; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU., Alswat AM; College of Medicine, King Abdullah International Medical Research Center, Jeddah, SAU.; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU., Banjar SA; College of Medicine, King Abdullah International Medical Research Center, Jeddah, SAU.; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU., Allam RF; College of Medicine, King Abdullah International Medical Research Center, Jeddah, SAU.; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU., Ahmed ME; College of Sciences and Health Professions, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU., Alzahrani A; Department of Cardiac Sciences, King Faisal Cardiac Center, Jeddah, SAU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Nov 23; Vol. 15 (11), pp. e49281. Date of Electronic Publication: 2023 Nov 23 (Print Publication: 2023).
DOI:	10.7759/cureus.49281
Abstrakt:	Background: Diabetes mellitus (DM) is a major chronic condition that is considered a strong indicator of poor cardiovascular outcomes, such as recurrent infarction and heart failure (HF), in individuals with acute myocardial infarction (AMI). However, the concept of left ventricular remodeling (LVR) following AMI in DM patients is not well understood and studied in Saudi Arabia. Thus, the aim of this study is to assess the association between LVR and DM in patients presenting with ST-elevation myocardial infarction (STEMI) who had reperfusion therapy with optimal medical therapy after percutaneous coronary intervention (PCI). Methods: In this retrospective cohort study, 171 patients diagnosed with AMI who visited King Faisal Cardiac Center in King Abdulaziz Medical City, National Guard Hospital, Jeddah, Saudi Arabia, were chosen via the convenience sampling method. The study included patients with AMI who received echocardiograms upon admission and during a follow-up period of six to 12 months. The patients were divided into two groups based on their diabetic status: diabetic (DM) and non-diabetic (non-DM). To collect the data, trained medical students supervised by the principal investigator used the patients' medical records. Results: The study showed that DM patients were more likely to have a history of hypertension, dyslipidemia, smoking, and stress hyperglycemia and had a higher hospitalization rate compared to the non-DM group. Although there was no statistically significant difference (p=0.253), both groups had a higher incidence of the left main trunk and/or left anterior descending artery affected. Regarding the echocardiographic finding, there were no significant differences between the two groups in terms of left ventricular ejection fraction, left ventricular internal diameter at end-diastole, left ventricular internal diameter at end-systole, and interventricular septum thickness. Conclusion: This paper suggests that there is no significant correlation between DM and non-DM patients in terms of LVR after AMI. However, DM patients had a statistically significant increased risk of developing HF and valvular heart disease compared to non-DM patients after AMI. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Albakistani et al.)
Databáze:	MEDLINE
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