| Autor: |
Fotso Tatio LF; Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon., Nouga Bissoue A; Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon., Tadjong Tcho A; Department of Chemistry, University of Buea, Faculty of Sciences, Buea, Cameroon., Akone SH; Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon.; Department of Microbial Natural Products (MINS), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), University of Saarland, Saarbrücken, Germany., Jounda NN; Process Engineering Laboratory, Department of Chemical Engineering, HTTTC, University of Douala, Douala, Cameroon., Tsopgni WDT; Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon., Kamdem Waffo AF; Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, Douala, Cameroon. |
| Abstrakt: |
The chemical investigation of the methanolic leaf extract of Trichilia dregeana Sond. led to the isolation of a hitherto unreported cycloartane-type triterpene, dregeanol ( 1 ), together with nine known compounds, (3 β ,23 E )-9,19-cyclolanosta-23,25-dien-3-ol ( 2 ), 9,19-cyclolanost-24-en-23-one ( 3 ), 6 β -hydroxystigmasta-4,22-dien-3-one ( 4 ), lyoniresinol ( 5 ), maslinic acid ( 6 ), asperphernamate ( 7 ), mixture of stigmasterol ( 8 ) and β -sitosterol ( 9 ) and β -sitosterol-3- O - β -D-glucopyranoside ( 10 ). The structures of the isolates were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. Compounds 2 and 6 showed significant antibacterial effect against Escherichia coli and Salmonella enteritidis , res-pectively, with MIC value of 31.25 μg/mL, whilst they displayed moderate antifungal effect with MIC value of 62.5 μg/mL against Candida albicans . All the isolates except compound 3 were found to possess a weak antioxidant potential in the DPPH, ABTS and FRAP assays. |
