Copaifera langsdorffii Desf. tree oleoresin-induced antinociception recruits µ 1 - and κ -opioid receptors in the ventrolateral columns of the periaqueductal gray matter.

Autor: Santana VC; Laboratory of Experimental Neuropsychobiology and Toxicology, Institute of Health Sciences, Federal University of Mato Grosso (UFMT), Av. Alexandre Ferronato, 1200, Reserva 35, Setor Industrial, Sinop 78557-267, Mato Grosso, Brazil., Marmentini BM; Laboratory of Experimental Neuropsychobiology and Toxicology, Institute of Health Sciences, Federal University of Mato Grosso (UFMT), Av. Alexandre Ferronato, 1200, Reserva 35, Setor Industrial, Sinop 78557-267, Mato Grosso, Brazil., Cruz GG; Laboratory of Experimental Neuropsychobiology and Toxicology, Institute of Health Sciences, Federal University of Mato Grosso (UFMT), Av. Alexandre Ferronato, 1200, Reserva 35, Setor Industrial, Sinop 78557-267, Mato Grosso, Brazil., de Jesus LC; Laboratory of Experimental Neuropsychobiology and Toxicology, Institute of Health Sciences, Federal University of Mato Grosso (UFMT), Av. Alexandre Ferronato, 1200, Reserva 35, Setor Industrial, Sinop 78557-267, Mato Grosso, Brazil., Walicheski L; Laboratory of Experimental Neuropsychobiology and Toxicology, Institute of Health Sciences, Federal University of Mato Grosso (UFMT), Av. Alexandre Ferronato, 1200, Reserva 35, Setor Industrial, Sinop 78557-267, Mato Grosso, Brazil., Beffa FH; Laboratory of Experimental Neuropsychobiology and Toxicology, Institute of Health Sciences, Federal University of Mato Grosso (UFMT), Av. Alexandre Ferronato, 1200, Reserva 35, Setor Industrial, Sinop 78557-267, Mato Grosso, Brazil., Maffei THP; Laboratory of Experimental Neuropsychobiology and Toxicology, Institute of Health Sciences, Federal University of Mato Grosso (UFMT), Av. Alexandre Ferronato, 1200, Reserva 35, Setor Industrial, Sinop 78557-267, Mato Grosso, Brazil., Streg RV; Laboratory of Experimental Neuropsychobiology and Toxicology, Institute of Health Sciences, Federal University of Mato Grosso (UFMT), Av. Alexandre Ferronato, 1200, Reserva 35, Setor Industrial, Sinop 78557-267, Mato Grosso, Brazil., Veiga-Junior VF; Chemical Engineering Section, Military Institute of Engineering, Praça General Tibúrcio, 80, Praia Vermelha, Urca, Rio de Janeiro, 22290-270 Rio de Janeiro, Brazil., Andrighetti CR; Laboratory of Pharmacognosy, Institute of Health Sciences, Mato Grosso Federal University (UFMT), Av. Alexandre Ferronato, 1200, Reserva 35, Setor Industrial, Sinop 78557-267, Mato Grosso, Brazil., Freitas de Lima MC; Federal University of Amazonas, Department of Chemistry, Av. General Rodrigo Octávio Jordão Ramos, 1200, Coroado I, Manaus 69067-005, Amazonas, Brazil., de Sousa Valladão DM; Laboratory of Quality Control, Institute of Health Sciences, Federal University of Mato Grosso (UFMT), Av. Alexandre Ferronato, 1200, Reserva 35, Setor Industrial, Sinop 78557-267, Mato Grosso, Brazil., de Oliveira RC; Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto School of Medicine of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto 14049-900, São Paulo, Brazil; Behavioural Neurosciences Institute (INeC), Av. Bandeirantes, 3900, Ribeirão Preto 14049-900, São Paulo, Brazil., Neyra MOC; Laboratory of Experimental Neuropsychobiology and Toxicology, Institute of Health Sciences, Federal University of Mato Grosso (UFMT), Av. Alexandre Ferronato, 1200, Reserva 35, Setor Industrial, Sinop 78557-267, Mato Grosso, Brazil., de Araújo Berber RC; Laboratory of Experimental Neuropsychobiology and Toxicology, Institute of Health Sciences, Federal University of Mato Grosso (UFMT), Av. Alexandre Ferronato, 1200, Reserva 35, Setor Industrial, Sinop 78557-267, Mato Grosso, Brazil., Falconi-Sobrinho LL; Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto School of Medicine of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto 14049-900, São Paulo, Brazil; Behavioural Neurosciences Institute (INeC), Av. Bandeirantes, 3900, Ribeirão Preto 14049-900, São Paulo, Brazil; NAP-USP-Neurobiology of Emotions Research Center (NuPNE), Ribeirão Preto Medical School of the University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto 14049-900, São Paulo, Brazil., Coimbra NC; Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto School of Medicine of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto 14049-900, São Paulo, Brazil; Behavioural Neurosciences Institute (INeC), Av. Bandeirantes, 3900, Ribeirão Preto 14049-900, São Paulo, Brazil; NAP-USP-Neurobiology of Emotions Research Center (NuPNE), Ribeirão Preto Medical School of the University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto 14049-900, São Paulo, Brazil., de Oliveira R; Laboratory of Experimental Neuropsychobiology and Toxicology, Institute of Health Sciences, Federal University of Mato Grosso (UFMT), Av. Alexandre Ferronato, 1200, Reserva 35, Setor Industrial, Sinop 78557-267, Mato Grosso, Brazil; Behavioural Neurosciences Institute (INeC), Av. Bandeirantes, 3900, Ribeirão Preto 14049-900, São Paulo, Brazil. Electronic address: ricardoliveira.ufmt@gmail.com.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2024 Mar 12; Vol. 461, pp. 114832. Date of Electronic Publication: 2023 Dec 23.
DOI: 10.1016/j.bbr.2023.114832
Abstrakt: Popular medicine has been using oleoresin from several species of copaíba tree for the treatment of various diseases and its clinical administration potentially causes antinociception. Electrical stimulation of ventrolateral (vlPAG) and dorsolateral (dlPAG) columns of the periaqueductal gray matter also causes antinociception. The aim this study was to verify the antinociceptive effect of oleoresin extracted from Copaifera langsdorffii tree and to test the hypothesis that oleoresin-induced antinociception is mediated by µ 1 - and κ-opioid receptors in the vlPAG and dlPAG. Nociceptive thresholds were determined by the tail-flick test in Wistar rats. The copaíba tree oleoresin was administered at different doses (50, 100 and 200 mg/kg) through the gavage technique. After the specification of the most effective dose of copaíba tree oleoresin (200 mg/kg), rats were pretreated with either the µ 1 -opioid receptor selective antagonist naloxonazine (at 0.05, 0.5 and 5 µg/ 0.2 µl in vlPAG, and 5 µg/ 0.2 µl in dlPAG) or the κ-opioid receptor selective antagonist nor-binaltorphimine (at 1, 3 and 9 nmol/ 0.2 µl in vlPAG, and 9 nmol/ 0.2 µl in dlPAG). The blockade of µ 1 and κ opioid receptors of vlPAG decreased the antinociception produced by copaíba tree oleoresin. However, the blockade of these receptors in dlPAG did not alter copaíba tree oleoresin-induced antinociception. These data suggest that vlPAG µ 1 and κ opioid receptors are critically recruited in the antinociceptive effect produced by oleoresin extracted from Copaifera langsdorffii.
Competing Interests: Declaration of Competing Interest The authors declare that there are no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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