The CEPH aging cohort and biobank: a valuable collection of biological samples from exceptionally long-lived French individuals and their offspring for longevity studies.

Autor: How-Kit A; Laboratory for Genomics, Foundation Jean Dausset - CEPH, Paris, France. alexandre.how-kit@fjd-ceph.org.; Laboratory of Excellence GenMed, Paris, France. alexandre.how-kit@fjd-ceph.org., Sahbatou M; Laboratory for Genomics, Foundation Jean Dausset - CEPH, Paris, France., Hardy LM; Laboratory for Genomics, Foundation Jean Dausset - CEPH, Paris, France.; Laboratory of Excellence GenMed, Paris, France., Tessier NP; Laboratory for Genomics, Foundation Jean Dausset - CEPH, Paris, France.; Laboratory of Excellence GenMed, Paris, France., Schiavon V; INSERM U976 - HIPI Unit, Saint-Louis Research Institute, University of Paris, Paris, France., Le Buanec H; INSERM U976 - HIPI Unit, Saint-Louis Research Institute, University of Paris, Paris, France., Sebaoun JM; Centre de Ressources Biologiques, Foundation Jean Dausset - CEPH, Paris, France., Blanché H; Laboratory of Excellence GenMed, Paris, France.; Centre de Ressources Biologiques, Foundation Jean Dausset - CEPH, Paris, France., Zagury JF; Équipe Génomique, Bioinformatique et Chimie Moléculaire (EA 7528), Conservatoire National Des Arts et Métiers, HESAM Université, Paris, France., Deleuze JF; Laboratory for Genomics, Foundation Jean Dausset - CEPH, Paris, France. deleuze@cnrgh.fr.; Laboratory of Excellence GenMed, Paris, France. deleuze@cnrgh.fr.; Centre de Ressources Biologiques, Foundation Jean Dausset - CEPH, Paris, France. deleuze@cnrgh.fr.; Centre National de Recherche en Génomique Humaine, CEA, Institut François Jacob, Evry, France. deleuze@cnrgh.fr.
Jazyk: angličtina
Zdroj: GeroScience [Geroscience] 2024 Apr; Vol. 46 (2), pp. 2681-2695. Date of Electronic Publication: 2023 Dec 23.
DOI: 10.1007/s11357-023-01037-4
Abstrakt: The increasing aging of the human population is currently and for the coming decades a major public health issue in many countries, requiring the implementation of global public health policies promoting healthy and successful aging. Individuals are not equal in the face of aging and some can present exceptional healthspan and/or lifespan, which are notably influenced by both genetic and environmental factors. Research and studies on human aging, healthy aging and longevity should rely in particular on cohorts of long-lived individuals, also including biological samples allowing studies on the biology of aging and longevity. In this manuscript, we provide for the first time a complete description of the CEPH (Centre d'Etude du Polymophisme Humain) Aging cohort, an exceptional cohort recruited during the 90s to 2000s, including more than 1700 French long-lived individuals (≥ 90 years old) born between 1875 and 1916 as well as for some of them their siblings and offspring. Among the participants, 1265 were centenarians, including 255 semi-supercentenarians ([105-110] years old) and 25 supercentenarians (≥ 110 years old). The available anthropometric, epidemiologic and clinical data for the cohort participants are described and especially the collection of blood-derived biological samples associated with the cohort which includes DNA, cryopreserved cells and cell lines, plasma, and serum. This biological collection from the first cohort of centenarians in the world is an inestimable resource for ongoing and future molecular, cellular, and functional studies aimed at deciphering the mechanisms of human (successful) aging and longevity.
(© 2023. The Author(s).)
Databáze: MEDLINE
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