Plasma concentration of leptin is related to food addiction in gambling disorder: Clinical and neuropsychological implications.

Autor:	Etxandi M; 1Clinical Psychology Unit, Bellvitge University Hospital, Barcelona, Spain.; 2Department of Psychiatry, Hospital Universitari Germans Trias i Pujol, IGTP Campus Can Ruti, Badalona, Spain.; 3Doctoral Program in Medicine and Translational Research, University of Barcelona (UB), Barcelona, Spain., Baenas I; 1Clinical Psychology Unit, Bellvitge University Hospital, Barcelona, Spain.; 3Doctoral Program in Medicine and Translational Research, University of Barcelona (UB), Barcelona, Spain.; 4Ciber Physiopathology of Obesity and Nutrition (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain.; 5Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Programme, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain., Mora-Maltas B; 1Clinical Psychology Unit, Bellvitge University Hospital, Barcelona, Spain.; 3Doctoral Program in Medicine and Translational Research, University of Barcelona (UB), Barcelona, Spain.; 5Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Programme, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain., Granero R; 4Ciber Physiopathology of Obesity and Nutrition (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain.; 5Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Programme, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.; 6Department of Psychobiology and Methodology, Autonomous University of Barcelona, Barcelona, Spain., Fernández-Aranda F; 1Clinical Psychology Unit, Bellvitge University Hospital, Barcelona, Spain.; 4Ciber Physiopathology of Obesity and Nutrition (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain.; 5Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Programme, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.; 7Department of Clinical Sciences, School of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain., Tovar S; 4Ciber Physiopathology of Obesity and Nutrition (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain.; 8Department of Physiology, CIMUS, University of Santiago de Compostela, Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., Solé-Morata N; 1Clinical Psychology Unit, Bellvitge University Hospital, Barcelona, Spain., Lucas I; 1Clinical Psychology Unit, Bellvitge University Hospital, Barcelona, Spain.; 4Ciber Physiopathology of Obesity and Nutrition (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain.; 5Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Programme, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain., Casado S; 4Ciber Physiopathology of Obesity and Nutrition (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain.; 8Department of Physiology, CIMUS, University of Santiago de Compostela, Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., Gómez-Peña M; 1Clinical Psychology Unit, Bellvitge University Hospital, Barcelona, Spain.; 5Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Programme, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain., Moragas L; 1Clinical Psychology Unit, Bellvitge University Hospital, Barcelona, Spain.; 5Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Programme, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain., Pino-Gutiérrez AD; 4Ciber Physiopathology of Obesity and Nutrition (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain.; 5Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Programme, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.; 9Department of Public Health, Mental Health and Perinatal Nursing, School of Nursing, University of Barcelona, Barcelona, Spain., Tapia J; 1Clinical Psychology Unit, Bellvitge University Hospital, Barcelona, Spain.; 3Doctoral Program in Medicine and Translational Research, University of Barcelona (UB), Barcelona, Spain.; 5Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Programme, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.; 10Medical Direction of Ambulatory Processes, South Metropolitan Territorial Management, Bellvitge University Hospital, Barcelona, Spain., Valenciano-Mendoza E; 1Clinical Psychology Unit, Bellvitge University Hospital, Barcelona, Spain., Potenza MN; 11Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; 12Child Study Center, Yale University School of Medicine, New Haven, CT, USA.; 13Connecticut Mental Health Center, New Haven, CT, USA.; 14Connecticut Council on Problem Gambling, Wethersfield, CT, USA.; 15Department of Neuroscience, Yale University, New Haven, CT, USA., Gearhardt AN; 16Department of Psychology, University of Michigan, Ann Arbor, USA., Diéguez C; 4Ciber Physiopathology of Obesity and Nutrition (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain.; 8Department of Physiology, CIMUS, University of Santiago de Compostela, Instituto de Investigación Sanitaria, Santiago de Compostela, Spain., Jiménez-Murcia S; 1Clinical Psychology Unit, Bellvitge University Hospital, Barcelona, Spain.; 4Ciber Physiopathology of Obesity and Nutrition (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain.; 5Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Programme, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.; 7Department of Clinical Sciences, School of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.
Jazyk:	angličtina
Zdroj:	Journal of behavioral addictions [J Behav Addict] 2023 Oct 17; Vol. 12 (4), pp. 1019-1031. Date of Electronic Publication: 2023 Oct 17 (Print Publication: 2023).
DOI:	10.1556/2006.2023.00051
Abstrakt:	Background: Data implicate overlaps in neurobiological pathways involved in appetite regulation and addictive disorders. Despite different neuroendocrine measures having been associated with both gambling disorder (GD) and food addiction (FA), how appetite-regulating hormones may relate to the co-occurrence of both entities remain incompletely understood. Aims: To compare plasma concentrations of ghrelin, leptin, adiponectin, and liver-expressed antimicrobial peptide 2 (LEAP-2) between patients with GD, with and without FA, and to explore the association between circulating hormonal concentrations and neuropsychological and clinical features in individuals with GD and FA. Methods: The sample included 297 patients diagnosed with GD (93.6% males). None of the patients with GD had lifetime diagnosis of an eating disorder. FA was evaluated with the Yale Food Addiction Scale 2.0. All patients were assessed through a semi-structured clinical interview and a psychometric battery including neuropsychological tasks. Blood samples to measure hormonal variables and anthropometric variables were also collected. Results: From the total sample, FA was observed in 23 participants (FA+) (7.7% of the sample, 87% males). When compared participants with and without FA, those with FA+ presented both higher body mass index (BMI) (p < 0.001) and leptin concentrations, after adjusting for BMI (p = 0.013). In patients with FA, leptin concentrations positively correlated with impulsivity, poorer cognitive flexibility, and poorer inhibitory control. Other endocrine measures did not differ between groups. Discussion and Conclusions: The present study implicates leptin in co-occurring GD and FA. Among these patients, leptin concentration has been associated with clinical and neuropsychological features, such as impulsivity and cognitive performance in certain domains.
Databáze:	MEDLINE
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