Effect of Zingiber Officinale in the Management of Nausea and Vomiting Induced by Treatment With Cisplatin Associated With Radiotherapy: A Randomized Controlled Trial.
| Autor: | Santos KVGD; Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., da Silva RLM; Institute of Education, Research and Innovation, Liga Contra o Câncer, Natal, Rio Grande do Norte, Brazil., Sarmento ACA; Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Medeiros KS; Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.; Institute of Education, Research and Innovation, Liga Contra o Câncer, Natal, Rio Grande do Norte, Brazil., Pessoa RL; Institute of Education, Research and Innovation, Liga Contra o Câncer, Natal, Rio Grande do Norte, Brazil., Dantas DV; Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Dantas RAN; Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Integrative cancer therapies [Integr Cancer Ther] 2023 Jan-Dec; Vol. 22, pp. 15347354231220608. |
| DOI: | 10.1177/15347354231220608 |
| Abstrakt: | Objective: evaluate the efficacy of Zingiber Officinale in the management of nausea and vomiting induced by treatment with cisplatin associated with radiotherapy in patients with uterine cervical neoplasms. Methods: a triple-blind, randomized, placebo-controlled trial. Interventions: Comparing the effects of ginger with institutional antiemetic therapy (ondansetron with dexamethasone). Patients with cervical cancer who started treatment with cisplatin with an indication of 40 mg/m² associated with radiotherapy, aged over 18 years, and with the ability to tolerate swallowing a capsule were recruited and equally allocated (1:1:1) into 3 groups of 16 patients each (the ginger capsules 250 mg group, ginger capsules 500 mg group, and placebo group). Nausea and vomiting were measured on baseline, 7 days after the first dose of medication and every seven consecutive days during a treatment break. Results: The 250 mg ginger group had an 8.0% greater chance of experiencing nausea within 24 h after the chemotherapy infusion than the placebo group, although there is no statistical significance ( P = .92986). The 500 mg ginger group showed a 63.9% reduction in nausea under the same conditions ( P = .40460). No change was detected in the occurrence of nausea episodes during the 6 weeks ( P = .8664) or between the groups ( P = .2817). No change was detected in acute or late vomiting during the 6 weeks ( P = .3510) or between the groups ( P = .8500 and P = .5389, respectively). Conclusion: Ginger supplementation does not reduce the intensity of acute and late nausea and vomiting. REBEC (RBR-47yx6p9). Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|