The association between pre-eclampsia and neonatal complications in relation to gestational age.

Autor: Ulfsdottir H; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Grandahl M; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden., Björk J; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden., Karlemark S; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden., Ekéus C; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Jazyk: angličtina
Zdroj: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2024 Mar; Vol. 113 (3), pp. 426-433. Date of Electronic Publication: 2023 Dec 23.
DOI: 10.1111/apa.17080
Abstrakt: Aim: There has been limited research about the associations between pre-eclampsia and neonatal complications in relation to gestational age. This register-based study aimed to address that gap in our knowledge.
Methods: We used Swedish Medical Birth Register to carry out a population-based study on primiparas with singleton pregnancies from 1999 to 2017. Descriptive statistics and logistic regressions were used to study the associations between pre-eclampsia and neonatal complications in different gestational ages. The data is presented as adjusted odds ratios (aORs) with 95% CI.
Results: The study comprised 805 591 primiparas: 2.9% had mild to moderate pre-eclampsia and 1.4% had severe pre-eclampsia. Neonates born to women with pre-eclampsia had increased risks of several complications compared to those born to mothers without pre-eclampsia. After adjustment for confounding variables, the risk of being small for gestational age (aOR 5.3, CI: 5.1-5.5) and needing resuscitation (aOR 2.6, CI: 2.4-2.7) were increased. The risk of a low Apgar score and convulsions/hypoxic ischemic encephalopathy was increased at 32-41 weeks of gestation. Moreover, the overall risk of sepsis (aOR 1.9. CI: 1.8-2.1) and perinatal death (aOR 1.2, CI: 1.1-1.5) was also increased.
Conclusion: Compared with infants of mothers without pre-eclampsia, those exposed to pre-eclampsia had higher risks of all the studied neonatal complications.
(© 2023 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.)
Databáze: MEDLINE
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