Risk Awareness as a Key Determinant of Early Vaccine Uptake in the Mpox Vaccination Campaign in an Italian Region: A Cross-Sectional Analysis.

Autor:	Del Duca G; Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy., Tavelli A; Icona Foundation, 20142 Milan, Italy., Mastrorosa I; Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy., Aguglia C; Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.; Department of System Medicine, University of Rome Tor Vergata, 00133 Rome, Italy., Lanini S; Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy., Brita AC; Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy., Gagliardini R; Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy., Vita S; Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy., Vergori A; Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy., Paulicelli J; Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy., Natalini G; Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy., D'Urso A; Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy., Piselli P; Department of Epidemiology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy., Gallì P; Health Direction, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy., Mondillo V; Health Direction, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy., Mastroianni C; Department of Public Health and Infectious Diseases, Sapienza University, AOU Policlinico Umberto 1, 00161 Rome, Italy., Tamburrini E; Fondazione Policlinico A. Gemelli, Catholic University of the Sacred Heart, 00168 Rome, Italy., Sarmati L; Department of System Medicine, University of Rome Tor Vergata, 00133 Rome, Italy., Stingone C; STI/HIV Unit, San Gallicano IRCCS Dermatological Institute, 00144 Rome, Italy., Lichtner M; Neuroscience Mental Health and Sense Organs Department, Sapienza University of Rome, Polo Pontino, 04100 Latina, Italy., Nicastri E; Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy., Farinella M; Circolo di Cultura Omosessuale Mario Mieli, 00146 Rome, Italy., Leserri F; Plus Roma, 00182 Rome, Italy., Siddu A; General Directorate of Prevention, Ministry of Health, 00197 Rome, Italy., Maggi F; Laboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy., d'Arminio Monforte A; Icona Foundation, 20142 Milan, Italy., Vairo F; Department of Epidemiology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy., Barca A; Unit of Health Promotion and Prevention, Directorate of Health and Integration, Lazio Region, 00145 Rome, Italy., Vaia F; General Directorate of Prevention, Ministry of Health, 00197 Rome, Italy., Girardi E; Scientific Direction, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy., Mazzotta V; Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy., Antinori A; Clinical Infectious Diseases Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.
Jazyk:	angličtina
Zdroj:	Vaccines [Vaccines (Basel)] 2023 Nov 27; Vol. 11 (12). Date of Electronic Publication: 2023 Nov 27.
DOI:	10.3390/vaccines11121761
Abstrakt:	Background: we aim to investigate attitudes toward vaccination by analyzing empirical factors associated with vaccine acceptance in the Lazio region mpox vaccination (MpoxVax) campaign in Italy. Methods: all subjects who accessed MpoxVax and signed the informed consent were prospectively enrolled in the MPOX-VAC Study and were asked to fill out an anonymous survey. Two endpoints were selected: 'delayed acceptance' and 'early acceptance', defined as access for vaccination >60 and ≤30 days from the vaccination campaign starting (VCS), respectively. Results: over the study period, 1717 individuals underwent vaccination: 129 (7%) > 60 [1588 (92.5%) ≤ 60] and 676 (60%) ≤ 30 days from VCS. A bisexual orientation, a lower education level and a worse perceived physical and mental health were associated with delayed access to vaccination. Being pre-exposure prophylaxis (PrEP) users and, marginally, HIV positive; having a high perceived risk for mpox infection; and reporting high-risk behaviors like the use of recreational drugs/chems, sex under the influence of drugs and/or alcohol and having a higher number of principal sexual partners, were associated with early access to vaccination. Conclusions: according to our data, risk awareness was a major determinant of early MpoxVax acceptance. Conversely, worse perceived health status and a low educational level were critical factors associated with delayed vaccination.
Databáze:	MEDLINE
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