Novel Organogels from Mauritia flexuosa L.f and Caryodendron orinocense Karst.: A Topical Alternative.

Autor: Narvaez LEM; Institute of Health Sciences, Federal University of Pará, Belém 66075-110, Brazil.; Sinchi Amazon Research Institute, Bogotá 110311, Colombia., Carrillo MP; Sinchi Amazon Research Institute, Bogotá 110311, Colombia., Cardona-Jaramillo JEC; Sinchi Amazon Research Institute, Bogotá 110311, Colombia., Vallejo BM; Health Sciences Institute, National University of Colombia, Bogotá 111321, Colombia., Ferreira LMMC; Institute of Health Sciences, Federal University of Pará, Belém 66075-110, Brazil., Silva-Júnior JOC; Institute of Health Sciences, Federal University of Pará, Belém 66075-110, Brazil., Ribeiro-Costa RM; Institute of Health Sciences, Federal University of Pará, Belém 66075-110, Brazil.
Jazyk: angličtina
Zdroj: Pharmaceutics [Pharmaceutics] 2023 Nov 27; Vol. 15 (12). Date of Electronic Publication: 2023 Nov 27.
DOI: 10.3390/pharmaceutics15122681
Abstrakt: Organogels have importance for topical applications because they can be used to deliver drugs in a controlled and prolonged fashion. These are materials consisting of a three-dimensional network of organic molecules dispersed in a solvent. Recent studies have demonstrated that the solvent could be replaced by oils from non-conventional biologic sources. There is a diversity of not-explored species in the Amazon that are promising sources of vegetable oils with a promising composition. This study developed an organogel with buriti ( Mauritia flexuosa L.f) and cacay ( Caryodendron orinocens e Karst.) oils, using cetostearyl alcohol as an organogelator due to its compatibility, stability, security, affordability, and it is readily available. The oils were characterized, and the organogels were synthesized by studying their crystal evolution and oil-binding capacity. The microstructure was evaluated with polarized light microscopy, fractal dimension, FTIR spectroscopy, XRD, and thermal and rheological analyses. It was found that the critical gelation concentration was higher for cacay oil as it possessed a higher amount of polyunsaturated triacylglycerols. The crystals of the buriti organogel had a smaller lamellar shape, a greater surface area, and physical and thermal stability; although, it presented a slower crystal evolution due to the low number of minor compounds and a greater number of saturated triacylglycerols. The polar fraction of the organogelators as well as triacylglycerol and minor polar compounds are important in forming crystallization nuclei. The study showed that Amazonian oils in crystallization processes form microstructures with differentiating physicochemical properties.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje