A Pilot Interaction Analysis of Gut Microbiota and Peripheral Markers of Aging in Severe Psychiatric Disorders: A Role for Lachnoclostridium ?

Autor: Manchia M; Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09127 Cagliari, Italy.; Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09127 Cagliari, Italy.; Department of Pharmacology, Dalhousie University, Halifax, NS B3H 4R2, Canada., Paribello P; Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09127 Cagliari, Italy.; Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09127 Cagliari, Italy., Pisanu C; Unit of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, 09042 Monserrato, Italy., Congiu D; Unit of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, 09042 Monserrato, Italy., Antoniades A; Stremble Ventures Ltd., Limassol 4042, Cyprus., Vogazianos P; Stremble Ventures Ltd., Limassol 4042, Cyprus., Tozzi F; Stremble Ventures Ltd., Limassol 4042, Cyprus., Pinna F; Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09127 Cagliari, Italy.; Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09127 Cagliari, Italy., Aristodimou A; Stremble Ventures Ltd., Limassol 4042, Cyprus., Caria P; Unit of Biology and Genetics, Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy., Dettori T; Unit of Biology and Genetics, Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy., Frau DV; Unit of Biology and Genetics, Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy., Cocco C; NEF Laboratory, Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy., Noli B; NEF Laboratory, Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy., Panebianco C; Gastreonterology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, 71013 San Giovanni Rotondo, Italy., Pazienza V; Gastreonterology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, 71013 San Giovanni Rotondo, Italy., Carpiniello B; Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09127 Cagliari, Italy.; Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09127 Cagliari, Italy., Squassina A; Unit of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, 09042 Monserrato, Italy.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2023 Dec 18; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 18.
DOI: 10.3390/ijms242417618
Abstrakt: Excessive predominance of pathological species in the gut microbiota could increase the production of inflammatory mediators at the gut level and, via modification of the gut-blood barrier, at the systemic level. This pro-inflammatory state could, in turn, increase biological aging that is generally proxied by telomere shortening. In this study, we present findings from a secondary interaction analysis of gut microbiota, aging, and inflammatory marker data from a cohort of patients with different diagnoses of severe mental disorders. We analyzed 15 controls, 35 patients with schizophrenia (SCZ), and 31 patients with major depressive disorder (MDD) recruited among those attending a community mental health center (50 males and 31 females, mean and median age 46.8 and 46.3 years, respectively). We performed 16S rRNA sequencing as well as measurement of telomere length via quantitative fluorescence in situ hybridization and high-sensitivity C-reactive protein. We applied statistical modeling with logistic regression to test for interaction between gut microbiota and these markers. Our results showed statistically significant interactions between telomere length and gut microbiota pointing to the genus Lachnostridium , which remained significantly associated with a reduced likelihood of MDD even after adjustment for a series of covariates. Although exploratory, these findings show that specific gut microbiota signatures overexpressing Lachnoclostridium and interacting with biological aging could modulate the liability for MDD.
Databáze: MEDLINE
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