| Autor: |
Kulagina DA; Laboratory for Medicinal Chemistry, Institute for Problems of Chemical and Energetic Technologies, Siberian Branch of the Russian Academy of Sciences (IPCET SB RAS), 659322 Biysk, Russia., Sysolyatin SV; Laboratory for Medicinal Chemistry, Institute for Problems of Chemical and Energetic Technologies, Siberian Branch of the Russian Academy of Sciences (IPCET SB RAS), 659322 Biysk, Russia., Krylova SG; Goldberg Research Institute of Pharmacology and Regenerative Medicine (GRIP&RM), Tomsk National Research Medical Center, Russian Academy of Sciences, 634028 Tomsk, Russia., Kiseleva EA; Goldberg Research Institute of Pharmacology and Regenerative Medicine (GRIP&RM), Tomsk National Research Medical Center, Russian Academy of Sciences, 634028 Tomsk, Russia., Povetyeva TN; Goldberg Research Institute of Pharmacology and Regenerative Medicine (GRIP&RM), Tomsk National Research Medical Center, Russian Academy of Sciences, 634028 Tomsk, Russia., Zueva EP; Goldberg Research Institute of Pharmacology and Regenerative Medicine (GRIP&RM), Tomsk National Research Medical Center, Russian Academy of Sciences, 634028 Tomsk, Russia., Eremina VV; Laboratory for Medicinal Chemistry, Institute for Problems of Chemical and Energetic Technologies, Siberian Branch of the Russian Academy of Sciences (IPCET SB RAS), 659322 Biysk, Russia., Alekseeva NA; Laboratory for Medicinal Chemistry, Institute for Problems of Chemical and Energetic Technologies, Siberian Branch of the Russian Academy of Sciences (IPCET SB RAS), 659322 Biysk, Russia., Strokova SV; Laboratory for Medicinal Chemistry, Institute for Problems of Chemical and Energetic Technologies, Siberian Branch of the Russian Academy of Sciences (IPCET SB RAS), 659322 Biysk, Russia., Suslov NI; Goldberg Research Institute of Pharmacology and Regenerative Medicine (GRIP&RM), Tomsk National Research Medical Center, Russian Academy of Sciences, 634028 Tomsk, Russia., Zhdanov VV; Goldberg Research Institute of Pharmacology and Regenerative Medicine (GRIP&RM), Tomsk National Research Medical Center, Russian Academy of Sciences, 634028 Tomsk, Russia. |
| Abstrakt: |
Biologically active compounds of natural or synthetic origin have a complex structure and generally contain various structural groups among which polycyclic cage amines are found. Hexaazaisowurtzitanes are representatives of these amines and studies on their biological activity began less than two decades ago, starting with research on the environmental impact of CL-20. This research helped to evaluate the risks of potential pollution in the habitat environments of living organisms and determine whether the chemical compounds in question could be utilized in pesticides, herbicides, fungicides, or medicinal drugs. The nomenclature of hexaazaisowurtzitane compounds has recently been expanded significantly, and some of them have demonstrated promise in the design of medicinal drugs. This paper review studies the pharmacological activity of the acyl derivatives of hexaazaisowurtzitane. Most of the compounds have been found to possess a high analgesic activity, providing a solution to the pressing issue of pain management in current pharmacology. Analgesic drugs currently used in the clinical practice do not meet all of the efficacy and safety requirements (gastro-, nephro-, hepato-, haematotoxicity, etc.). The material presented in the seven sections of this paper highlights information about hexaazaisowurtzitane derivatives. Furthermore, they have been observed to exhibit anti-inflammatory, anticonvulsant, antihypoxic, and antimetastatic activities, which render them highly promising for evaluation in various fields of medicinal practice. |
