An Operationally Simple Approach to Indole Derivatives from 2-Alkenylanilines Utilizing an Oxidation-Intramolecular Cyclization-Elimination Sequence.

Autor: Hines LN; Department of Chemistry, Radford University, Radford, VA 24142, USA., King JR; Department of Chemistry, Radford University, Radford, VA 24142, USA., Atwood AC; Department of Chemistry, Radford University, Radford, VA 24142, USA., Chapman RM; Department of Chemistry, Radford University, Radford, VA 24142, USA., Griffey MB; Department of Chemistry, Radford University, Radford, VA 24142, USA., Tutwiler CR; Department of Chemistry, Radford University, Radford, VA 24142, USA., Monceaux CJ; Department of Chemistry, Radford University, Radford, VA 24142, USA.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2023 Dec 06; Vol. 28 (24). Date of Electronic Publication: 2023 Dec 06.
DOI: 10.3390/molecules28247968
Abstrakt: Herein we describe a novel route to indole derivatives from a variety of N -substituted 2-alkenylanilines. This route features three operationally simple steps: (1) oxidation to convert N -substituted 2-alkenylanilines into epoxide intermediates, (2) intramolecular cyclization, and (3) the acid-catalyzed elimination of water.
Databáze: MEDLINE
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