Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus-A Case Report and Literature Review.

Autor: Santini M; Department for Infections in Immunocompromised Patients, University Hospital for Infectious Diseases 'Dr. Fran Mihaljević', 10000 Zagreb, Croatia.; School of Medicine, University of Zagreb, 10000 Zagreb, Croatia., Ljubić J; Infectious Diseases Department, County Hospital Čakovec, 40000 Čakovec, Croatia., Šoštar N; Emergency Department, University Hospital for Infectious Diseases 'Dr. Fran Mihaljević', 10000 Zagreb, Croatia., Vilibić-Čavlek T; School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.; Department of Virology, Croatian Institute of Public Health, 10000 Zagreb, Croatia., Bogdanić M; Department of Virology, Croatian Institute of Public Health, 10000 Zagreb, Croatia., Zakotnik S; Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia., Avšič-Županc T; Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia., Korva M; Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia., Kurolt IC; Research Department, University Hospital for Infectious Diseases 'Dr. Fran Mihaljević', 10000 Zagreb, Croatia., Radmanić L; Department for Molecular Diagnostics and Flow Cytometry, University Hospital for Infectious Diseases 'Dr. Fran Mihaljević', 10000 Zagreb, Croatia., Šimičić P; Department for Molecular Diagnostics and Flow Cytometry, University Hospital for Infectious Diseases 'Dr. Fran Mihaljević', 10000 Zagreb, Croatia., Krznarić J; School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.; Department of Intensive Care Medicine and Neuroinfectology, University Hospital for Infectious Diseases 'Dr. Fran Mihaljević', 10000 Zagreb, Croatia., Gjurašin B; Department of Intensive Care Medicine and Neuroinfectology, University Hospital for Infectious Diseases 'Dr. Fran Mihaljević', 10000 Zagreb, Croatia., Kutleša M; School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.; Department of Intensive Care Medicine and Neuroinfectology, University Hospital for Infectious Diseases 'Dr. Fran Mihaljević', 10000 Zagreb, Croatia., Višković K; Department of Radiology and Ultrasound, University Hospital for Infectious Diseases 'Dr. Fran Mihaljević', 10000 Zagreb, Croatia., Balent NC; Department of Clinical Microbiology, University Hospital for Infectious Diseases 'Dr. Fran Mihaljević', 10000 Zagreb, Croatia., Žunec R; Tissue Typing Laboratory, University Hospital Zagreb, 10000 Zagreb, Croatia., Margeta Marić I; County Hospital 'Dr. Josip Benčević', 35000 Slavonski Brod, Croatia., Ribarović A; County Hospital Zadar, 23000 Zadar, Croatia., Židovec-Lepej S; Department for Molecular Diagnostics and Flow Cytometry, University Hospital for Infectious Diseases 'Dr. Fran Mihaljević', 10000 Zagreb, Croatia.
Jazyk: angličtina
Zdroj: Microorganisms [Microorganisms] 2023 Dec 12; Vol. 11 (12). Date of Electronic Publication: 2023 Dec 12.
DOI: 10.3390/microorganisms11122963
Abstrakt: In this article, we report on a rare case of acute respiratory distress syndrome (ARDS) caused by the Puumala orthohantavirus (PUUV), which is typically associated with hemorrhagic fever with renal syndrome (HFRS). This is the first documented case of PUUV-associated ARDS in Southeast Europe. The diagnosis was confirmed by serum RT-PCR and serology and corroborated by phylogenetic analysis and chemokine profiling. The patient was a 23-year-old male from Zagreb, Croatia, who had recently traveled throughout Europe. He presented with fever, headache, abdominal pain, and sudden onset of ARDS. Treatment involved high-flow nasal cannula oxygen therapy and glucocorticoids, which resulted in a full recovery. A systematic literature review identified 10 cases of hantavirus pulmonary syndrome (HPS) caused by PUUV in various European countries and Turkey between 2002 and 2023. The median age of patients was 53 years (range 24-73), and six of the patients were male. Most patients were treated in intensive care units, but none received antiviral therapy targeting PUUV. Eight patients survived hospitalization. The presented case highlights the importance of considering HPS in the differential diagnosis of ARDS, even in areas where HFRS is the dominant form of hantavirus infection.
Databáze: MEDLINE
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