Early Adverse Family Experiences and Elevated Adrenocorticotropic Hormone Predict Non-Suicidal Self-Injury in Females with Non-Psychotic Mental Disorders and Suicidal Ideation.

Autor:	Zinchuk MS; Moscow Research and Clinical Center for Neuropsychiatry, 115419 Moscow, Russia., Druzhkova TA; Moscow Research and Clinical Center for Neuropsychiatry, 115419 Moscow, Russia., Popova SB; Moscow Research and Clinical Center for Neuropsychiatry, 115419 Moscow, Russia., Zhanina MY; Moscow Research and Clinical Center for Neuropsychiatry, 115419 Moscow, Russia.; Department of Functional Biochemistry of Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, Russia., Guekht AB; Moscow Research and Clinical Center for Neuropsychiatry, 115419 Moscow, Russia.; Department of Neurology, Neurosurgery and Medical Genetics, Pirogov Russian National Research Medical University, 119049 Moscow, Russia., Gulyaeva NV; Moscow Research and Clinical Center for Neuropsychiatry, 115419 Moscow, Russia.; Department of Functional Biochemistry of Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 117485 Moscow, Russia.
Jazyk:	angličtina
Zdroj:	Biomedicines [Biomedicines] 2023 Nov 29; Vol. 11 (12). Date of Electronic Publication: 2023 Nov 29.
DOI:	10.3390/biomedicines11123181
Abstrakt:	Nonsuicidal self-injurious behavior (NSSI), prevalent in patients with non-psychotic mental disorders (NPMD), is associated with numerous adverse outcomes. Despite active research into the clinical and psychological aspects of NSSI, the underlying biological mechanisms remain obscure. Early adverse experiences are believed to induce long-lasting changes in neuroendocrine mechanisms of stress control playing a key role in NSSI development. The aim of the study was to evaluate parameters potentially predicting development of NSSI in female patients with NPMD and suicidal ideation. Eighty female patients over 18 years with NPMD and suicidal ideation (40 with and 40 without NSSI) and 48 age matching women without evidence of mental illness (healthy controls) were enrolled. Diagnostic interviews and self-report measures were used to assess childhood maltreatment, presence, frequency, and characteristics of suicidal and self-injurious thoughts and behaviors, the Beck Depression Inventory scale to assess severity of depression. Hypothalamic-pituitary-adrenal axis markers, hormones, and neurotrophic factors were measured in blood serum. The likelihood of developing NSSI in patients with NPMD and suicidal ideation was associated with early adverse family history and elevated adrenocorticotropic hormone levels. Dysregulation of hypothalamic-pituitary-adrenal axis as a result of early chronic stress experiences may represent critical biological mechanism promoting the development of NSSI behaviors in patients with NPMD. Competing Interests: The authors declare no conflicts of interest.
Databáze:	MEDLINE
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