Exencephaly-Anencephaly Sequence Associated with Maxillary Brachygnathia, Spinal Defects, and Palatoschisis in a Male Domestic Cat.

Autor: Marc S; Faculty of Veterinary Medicine, University of Life Sciences 'King Mihai I' from Timisoara, Calea Aradului 119, 300645 Timisoara, Romania., Savici J; Faculty of Veterinary Medicine, University of Life Sciences 'King Mihai I' from Timisoara, Calea Aradului 119, 300645 Timisoara, Romania., Sicoe B; Faculty of Veterinary Medicine, University of Life Sciences 'King Mihai I' from Timisoara, Calea Aradului 119, 300645 Timisoara, Romania., Boldura OM; Faculty of Veterinary Medicine, University of Life Sciences 'King Mihai I' from Timisoara, Calea Aradului 119, 300645 Timisoara, Romania., Paul C; Department of Applied Chemistry and Engineering of Organic and Natural Compounds, Faculty of Industrial Chemistry and Environmental Engineering, Politehnica University Timisoara, Carol Telbisz 6, 300001 Timisoara, Romania., Otavă G; Faculty of Veterinary Medicine, University of Life Sciences 'King Mihai I' from Timisoara, Calea Aradului 119, 300645 Timisoara, Romania.
Jazyk: angličtina
Zdroj: Animals : an open access journal from MDPI [Animals (Basel)] 2023 Dec 17; Vol. 13 (24). Date of Electronic Publication: 2023 Dec 17.
DOI: 10.3390/ani13243882
Abstrakt: Anencephaly, a severe neural tube defect characterized by the absence of major parts of the brain and skull, is a rare congenital disorder that has been observed in various species, including cats. Considering the uncommon appearance of anencephaly, this paper aims to present anencephaly in a stillborn male kitten from an accidental inbreeding using various paraclinical methods. Histological examination of tissue samples from the cranial region, where parts of the skull were absent, revealed the presence of atypical nerve tissue with neurons and glial cells organized in clusters, surrounded by an extracellular matrix and with an abundance of blood vessels, which are large, dilated, and filled with blood, not characteristic of nerve tissue structure. In CT scans, the caudal part of the frontal bone, the fronto-temporal limits, and the parietal bone were observed to be missing. CT also revealed that the dorsal tubercle of the atlas, the dorsal neural arch, and the spinal process of the C2-C7 bones were missing. In conclusion, the kitten was affected by multiple congenital malformations, a combination of exencephaly-anencephaly, maxillary brachygnathism, closed cranial spina bifida at the level of cervical vertebrae, kyphoscoliosis, palatoschisis, and partial intestinal atresia. The importance of employing imaging techniques cannot be overstated when it comes to the accurate diagnosis of neural tube defects.
Databáze: MEDLINE
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