Acetylcholine muscarinic M1 receptors in the rodent prefrontal cortex modulate cognitive abilities to establish social hierarchy.

Autor: Chen WJ; Medical Research and Experimental Center, Meizhou People's Hospital, Meizhou, 514031, China.; Guangdong Engineering Technological Research Center of Clinical Molecular Diagnosis and Antibody Drugs, Meizhou, 514031, China., Chen H; Department of Neurobiology, Southern Medical University, Guangzhou, 510515, China., Li ZM; Department of Neurobiology, Southern Medical University, Guangzhou, 510515, China., Huang WY; Orthopedic Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China. hwyuan@126.com., Wu JL; Medical Research and Experimental Center, Meizhou People's Hospital, Meizhou, 514031, China. wujianlin@mzrmyy.com.; Guangdong Engineering Technological Research Center of Clinical Molecular Diagnosis and Antibody Drugs, Meizhou, 514031, China. wujianlin@mzrmyy.com.
Jazyk: angličtina
Zdroj: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2024 May; Vol. 49 (6), pp. 974-982. Date of Electronic Publication: 2023 Dec 22.
DOI: 10.1038/s41386-023-01785-z
Abstrakt: In most social species, the attainment of social dominance is strongly affected by personality traits. Dominant individuals show better cognitive abilities, however, whether an individual's cognition can determine its social status has remained inconclusive. We found that mice show better cognitive abilities tend to possess a higher social rank after cohousing. The dynamic release of acetylcholine (ACh) in the prelimbic cortex (PL) is correlated with mouse dominance behavior. ACh enhanced the excitability of the PL neurons via acetylcholine muscarinic M1 receptors (M1). Inhibition of M1 impaired mice cognitive performance and induced losing in social competition. Mice with M1 deficiency in the PL performed worse on cognitive behavioral tests, and exhibited lower status when re-grouped with others. Elevating ACh level in the PL of subordinate mice induced winning. These results provide direct evidence for the involvement of M1 in social hierarchy and suggest that social rank can be tuned by altering cognition through cholinergic system.
(© 2023. The Author(s), under exclusive licence to American College of Neuropsychopharmacology.)
Databáze: MEDLINE
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