Ent-labdane-type diterpene glycosides obtained from Rubus chingii Hu and their inhibitory effects on PDE5A activity.

Autor: Yu JD; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Wang JY; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Liu JY; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China., Xu YC; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China., Zhang X; Amway (Shanghai) Innovation & Science Co., Ltd., Shanghai 201203, China., Du J; Amway (Shanghai) Innovation & Science Co., Ltd., Shanghai 201203, China., Wu XH; Amway (Shanghai) Innovation & Science Co., Ltd., Shanghai 201203, China., Chen L; Amway (Shanghai) Innovation & Science Co., Ltd., Shanghai 201203, China. Electronic address: Clark.chen@amway.com., Wu YC; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: wuyingchun2013@163.com., Li YM; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: ymlius@163.com.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2024 Mar; Vol. 173, pp. 105780. Date of Electronic Publication: 2023 Dec 20.
DOI: 10.1016/j.fitote.2023.105780
Abstrakt: In this study, 16 new ent-labdane-type diterpene glycosides, designated as goshonosides J1-J16 (1-16), along with nine previously known diterpene glycosides (17-25) were extracted from the fruits of Rubus chingii Hu. The structures of goshonosides J1-J16 were elucidated using various analytical techniques, such as nuclear magnetic resonance, electron capture detector ECD, high-resolution electrospray ionization mass spectrometry HREIMS, single-crystal X-ray diffraction, and hydrolysis. Furthermore, the isolates' efficacy in inhibiting the activity of phosphodiesterase type 5 A was evaluated. Goshonosides J1, J2, and G effectively inhibited the activity of the aforementioned enzyme (IC 50 values: 6.15 ± 1.76, 3.27 ± 0.65, and 9.61 ± 2.36 μM, respectively). Our findings highlight the remarkable structural diversity of bioactive compounds in R. chingii Hu and offer insights into the use of this shrub.
Competing Interests: Declaration of Competing Interest Yingchun wu reports financial support was provided by Foundation for Innovative Research Groups of the National Natural Science Foundation of China.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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