Elevated soluble LOX-1 predicts risk of first-time myocardial infarction.
| Autor: | Schiopu A; Department of Clinical Sciences Malmö, Lund University, Sweden.; Department of Transitional Science, Lund University, Sweden., Björkbacka H; Department of Clinical Sciences Malmö, Lund University, Sweden., Narasimhan G; Department of Clinical Sciences Malmö, Lund University, Sweden., Loong BJ; Department of Clinical Sciences Malmö, Lund University, Sweden., Engström G; Department of Clinical Sciences Malmö, Lund University, Sweden., Melander O; Department of Clinical Sciences Malmö, Lund University, Sweden., Orho-Melander M; Department of Clinical Sciences Malmö, Lund University, Sweden., Nilsson J; Department of Clinical Sciences Malmö, Lund University, Sweden. |
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| Jazyk: | angličtina |
| Zdroj: | Annals of medicine [Ann Med] 2023; Vol. 55 (2), pp. 2296552. Date of Electronic Publication: 2023 Dec 22. |
| DOI: | 10.1080/07853890.2023.2296552 |
| Abstrakt: | Background: There is an unmet clinical need for novel therapies addressing the residual risk in patients receiving guideline preventive therapy for coronary heart disease. Experimental studies have identified a pro-atherogenic role of the oxidized LDL receptor LOX-1. We investigated the association between circulating soluble LOX-1 (sLOX-1) and the risk for development of myocardial infarction. Methods: The study subjects ( n = 4658) were part of the Malmö Diet and Cancer study. The baseline investigation was carried out 1991-1994 and the incidence of cardiovascular events monitored through national registers during a of 19.5 ± 4.9 years follow-up. sLOX-1 and other biomarkers were analyzed by proximity extension assay and ELISA in baseline plasma. Results: Subjects in the highest tertile of sLOX-1 had an increased risk of myocardial infarction (hazard ratio (95% CI) 1.76 (1.40-2.21) as compared with those in the lowest tertile. The presence of cardiovascular risk factors was related to elevated sLOX-1, but the association between sLOX-1 and risk of myocardial infarction remained significant when adjusting for risk factors. Conclusions: In this prospective population study we found an association between elevated sLOX-1, the presence of carotid disease and the risk for first-time myocardial infarction. Taken together with previous experimental findings of a pro-atherogenic role of LOX-1, this observation supports LOX-1 inhibition as a possible target for prevention of myocardial infarction. |
| Databáze: | MEDLINE |
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