Extended autoantibody panel in Turkish patients with early-stage systemic sclerosis: Coexpressions and their influences on clinical phenotypes.

Autor: Temiz Karadağ D; Department of Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey., Komac A; Department of Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey., Erez Y; Department of Rheumatology, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey., Birlik AM; Department of Rheumatology, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey., Sari A; Department of Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey., Akdoğan A; Department of Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey., Farisogullari B; Department of Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey., Kimyon G; Department of Rheumatology, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey., Koc E; Department of Rheumatology Adana, Faculty of Medicine, Cukurova University, Adana, Turkey., Arslan D; Department of Rheumatology Adana, Faculty of Medicine, Cukurova University, Adana, Turkey., Karatas A; Department of Rheumatology, Faculty of Medicine, Firat University, Elazig, Turkey., Koca SS; Department of Rheumatology, Faculty of Medicine, Firat University, Elazig, Turkey., Kasifoglu N; Department of Microbiology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey., Yazici A; Department of Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey., Hayran KM; Department of Preventive Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey., Cefle A; Department of Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.
Jazyk: angličtina
Zdroj: Immunity, inflammation and disease [Immun Inflamm Dis] 2023 Dec; Vol. 11 (12), pp. e1089.
DOI: 10.1002/iid3.1089
Abstrakt: Background/aim: To investigate the frequency and clinical relevance of an extended autoantibody profile in patients with systemic sclerosis (SSc).
Materials and Methods: In this cross-sectional study, serum from 100 consecutive patients was subjected to indirect immunofluorescence (IIF) (HEp-20-10/primate liver mosaic) and Systemic Sclerosis Profile by EUROIMMUN to evaluate anti-nuclear antibodies (ANA) and autoantibodies against 13 different autoantibodies in patients with SSc less than 3 years.
Results: Ninety-three of 100 patients were positive for ANA by IIF. Fifty-three patients showed single positivity, 26 anti-topoisomerase antibodies (anti-Scl70 ab), 16 anticentromere antibodies (ACAs), six anti-RNA polymerase III antibodies (anti-RNAPIII ab), one anti-Ku antibody, one anti-PM/Scl100 antibody, two anti-PM/Scl75 antibodies, one anti-Ro52 antibody, whereas 32 patients had multiple autoantibody positivities. Among classic SSc-specific autoantibodies, anti-Scl70 and anti-RNAPIII abs showed the highest cooccurrence (n = 4). One patient was simultaneously positive for anti-RNAPIII ab and ACA, and one was positive for ACA and anti-Scl70 ab. The clinical features were not statistically different between single and multiple autoantibody-positivity for classic SSc-specific autoantibodies (ACA, anti-Scl70 ab, and anti-RNAPIII ab), except for digital ulcer in the multiantibody positive ACA group (p = .019).
Conclusion: Based on our results, coexpression of autoantibodies is not uncommon in SSc patients. Although autoantibodies specific to SSc in early disease show generally known clinical features, it remains to be investigated how the coexpression of autoantibodies will affect clinical presentation.
(© 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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