Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project.

Autor: Su Y; Banner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, Arizona, USA., Protas H; Banner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, Arizona, USA., Luo J; Banner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, Arizona, USA., Chen K; Banner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, Arizona, USA., Alosco ML; Department of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA., Adler CH; Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA., Balcer LJ; Departments of Neurology, NYU Grossman School of Medicine, New York, New York, USA.; Department of Population Health and Ophthalmology, NYU Grossman School of Medicine, New York, New York, USA., Bernick C; Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA.; Department of Neurology, University of Washington, Seattle, Washington, USA., Au R; Department of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.; Framingham Heart Study, Framingham, Massachusetts, USA.; Slone Epidemiology Center; Departments of Anatomy & Neurobiology, Neurology, and Medicine, Department of Epidemiology, Boston University Chobanian & Avedisian School of Medicine; Boston University School of Public Health, Boston, Massachusetts, USA., Banks SJ; Departments of Neuroscience and Psychiatry, University of California, San Diego, California, USA., Barr WB; Departments of Neurology, NYU Grossman School of Medicine, New York, New York, USA., Coleman MJ; Departments of Psychiatry and Radiology, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Dodick DW; Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA., Katz DI; Department of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.; Encompass Health Braintree Rehabilitation Hospital, Braintree, Massachusetts, USA., Marek KL; Institute for Neurodegenerative Disorders, Invicro, LLC, New Haven, Connecticut, USA., McClean MD; Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA., McKee AC; Department of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.; VA Boston Healthcare System, Boston, Massachusetts, USA., Mez J; Department of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.; Framingham Heart Study, Framingham, Massachusetts, USA., Daneshvar DH; Department of Physical Medicine & Rehabilitation, Massachusetts General Hospital, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, Massachusetts, USA., Palmisano JN; Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Biostatistics and Epidemiology Data Analytics Center (BEDAC), Boston University School of Public Health, Boston, Massachusetts, USA., Peskind ER; Department of Psychiatry and Behavioral Sciences, VA Northwest Mental Illness Research, Education, and Clinical Center, VA Puget Sound Health Care System; University of Washington School of Medicine, Seattle, Washington, USA., Turner RW 2nd; Department of Clinical Research & Leadership, The George Washington University School of Medicine & Health Sciences, Washington, District of Columbia, USA., Wethe JV; Department of Psychiatry and Psychology, Mayo Clinic School of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA., Rabinovici G; Department of Neurology, University of California San Francisco, San Francisco, California, USA., Johnson K; Gordon Center for Medical Imaging, Mass General Research Institute, Harvard Medical School, Boston, Massachusetts, USA., Tripodis Y; Department of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Cummings JL; Department of Brain Health, Chambers-Grundy Center for Transformative Neuroscience, School of Integrated Health Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, USA., Shenton ME; Departments of Psychiatry and Radiology, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Stern RA; Department of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA., Reiman EM; Banner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, Arizona, USA.; University of Arizona, Arizona State University, Translational Genomics Research Institute, Phoenix, Arizona, USA.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Mar; Vol. 20 (3), pp. 1827-1838. Date of Electronic Publication: 2023 Dec 22.
DOI: 10.1002/alz.13602
Abstrakt: Introduction: Tau is a key pathology in chronic traumatic encephalopathy (CTE). Here, we report our findings in tau positron emission tomography (PET) measurements from the DIAGNOSE CTE Research Project.
Method: We compare flortaucipir PET measures from 104 former professional players (PRO), 58 former college football players (COL), and 56 same-age men without exposure to repetitive head impacts (RHI) or traumatic brain injury (unexposed [UE]); characterize their associations with RHI exposure; and compare players who did or did not meet diagnostic criteria for traumatic encephalopathy syndrome (TES).
Results: Significantly elevated flortaucipir uptake was observed in former football players (PRO+COL) in prespecified regions (p < 0.05). Association between regional flortaucipir uptake and estimated cumulative head impact exposure was only observed in the superior frontal region in former players over 60 years old. Flortaucipir PET was not able to differentiate TES groups.
Discussion: Additional studies are needed to further understand tau pathology in CTE and other individuals with a history of RHI.
(© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
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