Relationship between ETCO 2 and PaCO 2 under Changing Capnogram in Ventilated Infants with NAVA: An Observational Study.

Autor: Takahashi D; Division of Neonatology, Fukuda Hospital, 2-2-6, Shinmachi, Chuou-Ku, Kumamoto, 860-0004, Japan. daijiro@fukuda-hp.or.jp.; Division of Pediatrics, Fukuda Hospital, Kumamoto, Japan. daijiro@fukuda-hp.or.jp., Goto K; Division of Neonatology, Fukuda Hospital, 2-2-6, Shinmachi, Chuou-Ku, Kumamoto, 860-0004, Japan., Goto K; Division of Pediatrics, Fukuda Hospital, Kumamoto, Japan.
Jazyk: angličtina
Zdroj: Indian journal of pediatrics [Indian J Pediatr] 2024 Oct; Vol. 91 (10), pp. 1072-1074. Date of Electronic Publication: 2023 Dec 22.
DOI: 10.1007/s12098-023-04976-0
Abstrakt: This observational study evaluated the validity of end-tidal CO 2 (ETCO 2 ) as a surrogate for arterial PCO 2 (PaCO 2 ) in infants on neurally adjusted ventilatory assist (NAVA), particularly considering the influence of variable spontaneous breathing on capnography waveforms. The study involved 16 infants, analyzing 50 paired ETCO 2 and PaCO 2 values. Deming regression analysis highlighted a notably stronger correlation for maximum ETCO 2 (r 2  = 0.6783, p <0.0001) compared to mean ETCO 2 (r 2  = 0.5686, p <0.0001) and demonstrated a significantly weaker association for minimum ETCO 2 (r 2  = 0.1838). These findings emphasize the superior predictive value of maximum ETCO 2 in estimating PaCO 2 , advocating its reliable use in clinical monitoring, especially given the dynamic capnography associated with NAVA's variable pressures. The results suggest ETCO 2 's potential to enhance noninvasive respiratory management, reduce the frequency of blood sampling, and improve overall care for infants requiring mechanical ventilation.
(© 2023. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation.)
Databáze: MEDLINE
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