In vitro assessment of antibacterial and antiviral activity of three copper products after 200 rounds of simulated use.

Autor: Charles MK; Division of Medical Microbiology and Infection Prevention and Control, Vancouver Coastal Health, Vancouver, BC, Canada. marthe.charles@vch.ca.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada. marthe.charles@vch.ca.; Vancouver, Canada. marthe.charles@vch.ca., Williams TC; Division of Medical Microbiology and Infection Prevention and Control, Vancouver Coastal Health, Vancouver, BC, Canada., Nakhaie D; Department of Materials Engineering, University of British Columbia, Vancouver, BC, Canada., Woznow T; Division of Medical Microbiology and Infection Prevention and Control, Vancouver Coastal Health, Vancouver, BC, Canada., Velapatino B; Division of Medical Microbiology and Infection Prevention and Control, Vancouver Coastal Health, Vancouver, BC, Canada., Lorenzo-Leal AC; Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Bach H; Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Bryce EA; Division of Medical Microbiology and Infection Prevention and Control, Vancouver Coastal Health, Vancouver, BC, Canada., Asselin E; Department of Materials Engineering, University of British Columbia, Vancouver, BC, Canada.; Vancouver, Canada.
Jazyk: angličtina
Zdroj: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine [Biometals] 2024 Aug; Vol. 37 (4), pp. 849-856. Date of Electronic Publication: 2023 Dec 22.
DOI: 10.1007/s10534-023-00572-z
Abstrakt: Copper has well-documented antibacterial effects but few have evaluated it after prolonged use and against bacteria and viruses. Coupons from three copper formulations (solid, thermal coating, and decal applications) and carbon steel controls were subjected to 200 rounds simulated cleaning using a Wiperator™ and either an accelerated hydrogen peroxide, quaternary ammonium, or artificial sweat products. Antibacterial activity against S. aureus and P. aeruginosa was then evaluated using a modified Environmental Protection Agency protocol. Antiviral activity against coronavirus (229E) and norovirus (MNV-1) surrogates was assessed using the TCID 50 method. Results were compared to untreated control coupons. One hour after inoculation, S. aureus exhibited a difference in log kill of 1.16 to 4.87 and P. aeruginosa a log kill difference of 3.39-5.23 (dependent upon copper product and disinfectant) compared to carbon steel. MNV-1 demonstrated an 87-99% reduction on each copper surfaces at 1 h and 99% reduction at 2 h compared to carbon steel. Similarly, coronavirus 229E exhibited a 97-99% reduction after 1 h and 90-99% after 2 h. Simulated use with artificial sweat did not hinder the antiviral nor the antibacterial activity of Cu surfaces. Self-sanitizing copper surfaces maintained antibacterial and antiviral activity after 200 rounds of simulated cleaning.
(© 2023. The Author(s).)
Databáze: MEDLINE
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