| Autor: |
Dudašova Petrovičova O; Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia., Stanković I; Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia., Ðordević B; Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia., Dopsaj V; Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia., Milinković N; Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia., Dopsaj M; Faculty of Sport and Physical Education, University of Belgrade, Blagoja Parovića 156, 11000 Belgrade, Serbia. |
| Jazyk: |
angličtina |
| Zdroj: |
Metabolites [Metabolites] 2023 Dec 17; Vol. 13 (12). Date of Electronic Publication: 2023 Dec 17. |
| DOI: |
10.3390/metabo13121200 |
| Abstrakt: |
A randomized, double-blind, placebo-controlled study was conducted to investigate the influence of supplementation with a superoxide dismutase (SOD)-rich plant extract on markers of oxidative stress, zonulin levels and the performance of elite athletes. Participants were 30 international-level rowers, divided into an experimental group ( n = 15) and a control group ( n = 15). The rowers performed a maximal effort incremental test on a rowing ergometer at the beginning and at the end of the study. Markers of oxidative stress (total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), superoxide dismutase (SOD), glutathione peroxidase (GPx), advanced oxidation protein products (AOPPs), malondialdehyde (MDA), sulfhydryl (SH) groups, bilirubin, uric acid, albumin and zonulin) were determined in serum. A lower TOS ( p = 0.010) and OSI ( p = 0.004), a lower MDA ( p = 0.001) and a higher level of SH groups ( p = 0.031) were observed in the experimental group after supplementation. Physical performance was evaluated through metabolic efficiency, taking lactate levels and power output on the ergometer into account. After 6 weeks of supplementation, the relative increase in metabolic efficiency at a 4 mmol/L lactate concentration and maximal effort was significantly higher in the experimental group ( p = 0.004 and p = 0.015, respectively). These results suggest that supplementation with a SOD-rich extract promotes lower oxidative stress, better antioxidant protection and, consequently, the better work performance of athletes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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