| Autor: |
Udoye CC; Institute for Systemic Inflammation Research, University of Lübeck, 23562 Lübeck, Germany., Ehlers M; Laboratories of Immunology and Antibody Glycan Analysis, Institute for Nutritional Medicine, University of Lübeck and University Medical Center Schleswig-Holstein, 23538 Lübeck, Germany., Manz RA; Institute for Systemic Inflammation Research, University of Lübeck, 23562 Lübeck, Germany. |
| Jazyk: |
angličtina |
| Zdroj: |
Biology [Biology (Basel)] 2023 Dec 07; Vol. 12 (12). Date of Electronic Publication: 2023 Dec 07. |
| DOI: |
10.3390/biology12121501 |
| Abstrakt: |
Food allergies are a growing public health concern worldwide, especially in children and young adults. Allergen-specific IgE plays a central role in the pathogenesis of food allergies, but their titers poorly correlate with allergy development. Host immune systems yield allergen-specific immunoglobulin (Ig)A, IgE and IgG subclasses with low or high affinities and differential Fc N -glycosylation patterns that can affect the allergic reaction to food in multiple ways. High-affinity IgE is required to induce strong mast cell activation eventually leading to allergic anaphylaxis, while low-affinity IgE can even inhibit the development of clinically relevant allergic symptoms. IgA and IgG antibodies can inhibit IgE-mediated mast cell activation through various mechanisms, thereby protecting IgE-positive individuals from allergy development. The production of IgE and IgG with differential allergenic potential seems to be affected by the signaling strength of individual B cell receptors, and by cytokines from T cells. This review provides an overview of the diversity of the B cell response and the diverse roles of antibodies in food allergy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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