Hypertension in NF1: A closer look at the primacy of essential hypertension versus secondary causes.

Autor: Loponen N; Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland., Ylä-Outinen H; Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland.; Department of Pulmonary Diseases, Turku University Hospital, Turku, Finland., Kallionpää RA; Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland., Valtanen M; Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland.; Department of Mathematics and Statistics, University of Turku, Turku, Finland.; Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland., Auranen K; Department of Mathematics and Statistics, University of Turku, Turku, Finland.; Department of Clinical Medicine, University of Turku, Turku, Finland., Järveläinen H; Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland.; Department of Internal Medicine, Satakunta Central Hospital, Pori, Finland., Peltonen S; Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland.; Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Dermatology and Venereology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Dermatology and Allergology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Peltonen J; Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland.
Jazyk: angličtina
Zdroj: Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2024 Jan; Vol. 12 (1), pp. e2346. Date of Electronic Publication: 2023 Dec 22.
DOI: 10.1002/mgg3.2346
Abstrakt: Background: We aimed to analyze hypertension in neurofibromatosis type 1 (NF1) in a Finnish population-based cohort in 1996-2014.
Methods: A cohort of 1365 individuals with confirmed NF1 was compared with a control cohort of 13,923 individuals matched for age, sex, and area of residence. Diagnoses of hypertension were retrieved from the Finnish Care Register for Health Care. These registered data were separately analyzed for secondary and essential hypertension. Purchases of antihypertensive drugs were queried from the Finnish Register of Reimbursed Drug Purchases.
Results: We identified 115 NF1 patients with hospital diagnosis of hypertension. Our findings revealed a hazard ratio (HR) of 1.64 (95% CI 1.34-2.00, p < 0.001) in NF1 versus controls. NF1 patients presented with a significantly increased hazard for both secondary hypertension (n = 9, HR 3.76, 95% CI 1.77-7.95, p < 0.001) and essential hypertension (n = 98, HR 1.73, 95% CI 1.39-2.14, p < 0.001). No difference in the HR of hypertension was observed between men and women, while NF1 patients with essential hypertension were, on average, younger than the controls. The proportions of individuals with antihypertensive medication did not differ between NF1 patients and controls (OR 0.85).
Conclusion: NF1 is a risk factor for hypertension. Despite the recognized risk for secondary hypertension, essential hypertension is the predominant type in NF1.
(© 2023 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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