ROS regulation in gliomas: implications for treatment strategies.

Autor:	Yang YC; Department of Traditional Chinese Medicine, Tangdu Hospital, Air Force Medical University (Fourth Military Medical University), Xi'an, China., Zhu Y; College of Health, Dongguan Polytechnic, Dongguan, China.; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China., Sun SJ; Department of Postgraduate Work, Xi'an Medical University, Xi'an, China., Zhao CJ; Department of Traditional Chinese Medicine, Tangdu Hospital, Air Force Medical University (Fourth Military Medical University), Xi'an, China., Bai Y; Department of Neurosurgery, General Hospital of Northern Theater Command, Shenyang, China., Wang J; Department of Radiation Protection Medicine, Faculty of Preventive Medicine, Air Force Medical University (Fourth Military Medical University), Xi'an, China.; Shaanxi Key Laboratory of Free Radical and Medicine, Xi'an, China., Ma LT; Department of Traditional Chinese Medicine, Tangdu Hospital, Air Force Medical University (Fourth Military Medical University), Xi'an, China.; Key Laboratory of Integrated Traditional Chinese and Western Medicine Tumor Diagnosis and Treatment in Shaanxi Province, Xi'an, China.; Department of Gastroenterology, Tangdu Hospital, Air Force Medical University (Fourth Military Medical University), Xi'an, China.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2023 Dec 07; Vol. 14, pp. 1259797. Date of Electronic Publication: 2023 Dec 07 (Print Publication: 2023).
DOI:	10.3389/fimmu.2023.1259797
Abstrakt:	Gliomas are one of the most common primary malignant tumours of the central nervous system (CNS), of which glioblastomas (GBMs) are the most common and destructive type. The glioma tumour microenvironment (TME) has unique characteristics, such as hypoxia, the blood-brain barrier (BBB), reactive oxygen species (ROS) and tumour neovascularization. Therefore, the traditional treatment effect is limited. As cellular oxidative metabolites, ROS not only promote the occurrence and development of gliomas but also affect immune cells in the immune microenvironment. In contrast, either too high or too low ROS levels are detrimental to the survival of glioma cells, which indicates the threshold of ROS. Therefore, an in-depth understanding of the mechanisms of ROS production and scavenging, the threshold of ROS, and the role of ROS in the glioma TME can provide new methods and strategies for glioma treatment. Current methods to increase ROS include photodynamic therapy (PDT), sonodynamic therapy (SDT), and chemodynamic therapy (CDT), etc., and methods to eliminate ROS include the ingestion of antioxidants. Increasing/scavenging ROS is potentially applicable treatment, and further studies will help to provide more effective strategies for glioma treatment. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Yang, Zhu, Sun, Zhao, Bai, Wang and Ma.)
Databáze:	MEDLINE
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