Immunopathogenesis of Type 1 and Type 2 Leprosy Reaction: An Update Review.

Autor:	Dewi DAR; Department of Dermatovenereology, Faculty of Military Medicine, The Republic of Indonesia Defense University, Bogor, IDN.; Department of Dermatovenereology, Gatot Soebroto Central Army Hospital, Central Jakarta, IDN., Djatmiko CBP; Department of Dermatovenereology, Faculty of Military Medicine, The Republic of Indonesia Defense University, Bogor, IDN., Rachmawati I; Department of Dermatovenereology, Faculty of Military Medicine, The Republic of Indonesia Defense University, Bogor, IDN., Arkania N; Department of Dermatovenereology, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Yogyakarta, IDN., Wiliantari NM; Department of Dermatovenereology, Ratna Dewi Principal Clinic, Bekasi, IDN., Nadhira F; Department of Dermatovenereology, Ratna Dewi Principal Clinic, Bekasi, IDN.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Nov 21; Vol. 15 (11), pp. e49155. Date of Electronic Publication: 2023 Nov 21 (Print Publication: 2023).
DOI:	10.7759/cureus.49155
Abstrakt:	Leprosy reactions are acute exacerbations of the signs and symptoms of leprosy occurring during the natural course of the disease and during or after treatment. Left untreated or improperly managed, reactions can lead to severe nerve function impairment and subsequently to disabilities. In the present context of leprosy eradication efforts, leprosy reactions continue to pose a significant and enduring challenge. Type 1 leprosy reaction and type 2 leprosy reaction are substantial contributors to nerve impairment and the subsequent development of enduring impairments. The study of immunopathogenesis of leprosy reactions has emerged as a significant area of research due to its potential to identify critical targets for the early detection and management of these episodes. This study aims to reveal the pathogenesis of type 1 and 2 leprosy reactions so that they can form the basis for their treatment. The study used scientific journals from reputable platforms such as PubMed, Scopus, and Google Scholar to evaluate the pathogenesis of leprosy reaction type 1 and 2 in leprosy patients. This review indicates that the progression of leprosy nerve damage and sensitivity to reactions may be predicted using genetic and serum markers in the human host. A more profound comprehension of the molecular processes underlying leprosy reactions may offer a logical plan for early detection and leprosy reaction complication prevention. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Dewi et al.)
Databáze:	MEDLINE
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