In Vitro Synergistic Activity of Combinations of Tetrahydroisoquinolines and Treatment Antibiotics against Multidrug-Resistant Salmonella .

Autor: Ndip RA; Department of Biochemistry and Molecular Biology, University of Buea, P.O. Box 63, Buea, Cameroon., Hanna JN; Department of Chemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon., Mbah JA; Department of Chemistry, Faculty of Science, University of Buea, P.O. Box 63, Buea, Cameroon., Ghogomu SM; Department of Biochemistry and Molecular Biology, University of Buea, P.O. Box 63, Buea, Cameroon., Ngemenya MN; Department of Biochemistry and Molecular Biology, University of Buea, P.O. Box 63, Buea, Cameroon.; Department of Medical Laboratory Sciences, University of Buea, P.O. Box 63, Buea, Cameroon.
Jazyk: angličtina
Zdroj: Advances in pharmacological and pharmaceutical sciences [Adv Pharmacol Pharm Sci] 2023 Dec 13; Vol. 2023, pp. 6142810. Date of Electronic Publication: 2023 Dec 13 (Print Publication: 2023).
DOI: 10.1155/2023/6142810
Abstrakt: The global burden of Salmonella infections remains high due to the emergence of multidrug resistance to all recommended treatment antibiotics. Tetrahydroisoquinolines (THIQs) have demonstrated promising activity against multidrug-resistant (MDR) Salmonella Typhi. Hence, their interaction with treatment antibiotics was investigated for possible synergy. Twenty combinations of five THIQs ( 1 , 2 , 3 , 4, and 5 ) and four antibiotics were tested against each of 7 Salmonella isolates by the checkerboard method giving a total of 140 assays performed. Fractional inhibitory concentration indices (FICIs) were calculated, and isobolograms were plotted. In terms of FICI, synergism ranged from 0.078 to 0.5 and the highest magnitude (0.078) was recorded for chloramphenicol-THIQ 1 combination. In a total of 140 antibiotics-THIQs combination assays, 27 were synergistic (17%), 42 were additive (30%), 11 were antagonistic (7.8%), and 60 were indifferent (42%). The synergistic activity recorded for each antibiotic class in combination based on the total of 7 bacterial isolates tested ranged from 14.29% to 71.43%; the highest percentage was recorded for two combinations (chloramphenicol or sulphamethoxazole with THIQ 1 ). Ciprofloxacin-THIQ 1 combination showed additivity on all bacteria isolates tested (100%). Overall, THIQ 1 was the most synergistic and most additive in combination with three antibiotics (ampicillin, chloramphenicol, or sulphamethoxazole-trimethoprim). Some combinations of the THIQs and treatment antibiotics have shown high synergism which could potentially be efficacious against multidrug-resistant S. Typhi, hence this interaction should be further studied in vivo .
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2023 Rita Ayuk Ndip et al.)
Databáze: MEDLINE
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