Aetiology, risk factors and microbiota composition in children with prolonged diarrhoea: A prospective case-controlled cohort study.

Autor: Lo Vecchio A; Department of Translational Medical Science-Section of Pediatrics, University of Naples Federico II, Naples, Italy., Quitadamo P; Pediatric Gastroenterology and Hepatology Unit, Santobono-Pausilipon Children's Hospital, Naples, Italy., Poeta M; Department of Translational Medical Science-Section of Pediatrics, University of Naples Federico II, Naples, Italy., Buccigrossi V; Department of Translational Medical Science-Section of Pediatrics, University of Naples Federico II, Naples, Italy., Siani P; Department of Pediatrics, Santobono-Pausilipon Children's Hospital, Naples, Italy., Cioffi V; Department of Translational Medical Science-Section of Pediatrics, University of Naples Federico II, Naples, Italy., Ercolini D; Department of Agricultural Sciences, University of Naples Federico II, Portici, Italy., Guarino A; Department of Translational Medical Science-Section of Pediatrics, University of Naples Federico II, Naples, Italy.
Jazyk: angličtina
Zdroj: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2024 Mar; Vol. 113 (3), pp. 598-605. Date of Electronic Publication: 2023 Dec 21.
DOI: 10.1111/apa.17073
Abstrakt: Aim: Prolonged diarrhoea (ProD) refers to acute-onset diarrhoea that persists for longer than 1 week. As the aetiology, risk factors and management are poorly defined, we prospectively enrolled children hospitalised in a high-income setting to assess these outcomes and investigate the potential role of gut microbiota.
Methods: All children aged 30 days to 14 years admitted for acute-onset diarrhoea lasting 7-14 days were included. Children consecutively admitted in the same period for acute diarrhoea (AD) served as controls. High-throughput sequencing of 16S rRNA gene amplicons was used to analyse stool samples from a subset of patients and healthy controls.
Results: Sixty-eight with ProD and 104 with AD were enrolled. Intestinal infections were the main aetiology of diarrhoea in both groups (ProD 92.9% vs. AD 97.8%). ProD children showed a higher prevalence of bacterial infections compared to AD (30.8% vs. 8.9%, p = 0.024). Neither age, host-related factors, nor microbiome alterations were specifically linked to ProD. However, ProD children had a more severe initial clinical presentation than AD.
Conclusion: ProD is often the result of an unusually severe intestinal infection that runs a course longer than expected but generally resolves without further problems. No specific management or therapies should be undertaken in most cases.
(© 2023 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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