From cells to organs: progress and potential in cartilaginous organoids research.

Autor: Wang XH; Department of Bone and Joint Surgery, the First Affliated Hospital, Jinan University, Guangzhou, 510630, Guangdong, China., Liu N; Department of Bone and Joint Surgery, the First Affliated Hospital, Jinan University, Guangzhou, 510630, Guangdong, China., Zhang H; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, Anhui, China., Yin ZS; Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, Anhui, China., Zha ZG; Department of Bone and Joint Surgery, the First Affliated Hospital, Jinan University, Guangzhou, 510630, Guangdong, China. wxhtgy@126.com.
Jazyk: angličtina
Zdroj: Journal of translational medicine [J Transl Med] 2023 Dec 21; Vol. 21 (1), pp. 926. Date of Electronic Publication: 2023 Dec 21.
DOI: 10.1186/s12967-023-04591-9
Abstrakt: While cartilage tissue engineering has significantly improved the speed and quality of cartilage regeneration, the underlying metabolic mechanisms are complex, making research in this area lengthy and challenging. In the past decade, organoids have evolved rapidly as valuable research tools. Methods to create these advanced human cell models range from simple tissue culture techniques to complex bioengineering approaches. Cartilaginous organoids in part mimic the microphysiology of human cartilage and fill a gap in high-fidelity cartilage disease models to a certain extent. They hold great promise to elucidate the pathogenic mechanism of a diversity of cartilage diseases and prove crucial in the development of new drugs. This review will focus on the research progress of cartilaginous organoids and propose strategies for cartilaginous organoid construction, study directions, and future perspectives.
(© 2023. The Author(s).)
Databáze: MEDLINE
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