A rapid, non-invasive, clinical surveillance for CachExia, sarcopenia, portal hypertension, and hepatocellular carcinoma in end-stage liver disease: the ACCESS-ESLD study protocol.

Autor: Nasr P; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.; Wallenberg Centre for Molecular Medicine, Linköping University, Linköping, Sweden., Forsgren M; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.; AMRA Medical AB, Linköping, Sweden., Balkhed W; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden., Jönsson C; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden., Dahlström N; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden., Simonsson C; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.; Department of Biomedical Engineering, Linköping University, Linköping, Sweden., Cai S; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.; Department of Biomedical Engineering, Linköping University, Linköping, Sweden., Cederborg A; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.; Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden., Henriksson M; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden., Stjernman H; Department of Internal Medicine, Ryhov Hospital Jönköping, Jönköping, Sweden., Rejler M; Department of Medicine, Höglandssjukhuset Eksjö, Region Jönköping County Council, Jönköping, Sweden.; The Jönköping Academy for Improvement of Health and Welfare, Hälsohögskolan, Jönköping University, Jönköping, Sweden., Sjögren D; Department of Medicine, Höglandssjukhuset Eksjö, Region Jönköping County Council, Jönköping, Sweden., Cedersund G; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.; Department of Biomedical Engineering, Linköping University, Linköping, Sweden.; School of Medical Sciences and Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro, Sweden., Bartholomä W; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden., Rydén I; Department of Research, Region Kalmar County, Kalmar, Sweden.; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Lundberg P; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden., Kechagias S; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden., Leinhard OD; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.; AMRA Medical AB, Linköping, Sweden., Ekstedt M; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden. mattias.ekstedt@liu.se.; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden. mattias.ekstedt@liu.se.
Jazyk: angličtina
Zdroj: BMC gastroenterology [BMC Gastroenterol] 2023 Dec 21; Vol. 23 (1), pp. 454. Date of Electronic Publication: 2023 Dec 21.
DOI: 10.1186/s12876-023-03093-8
Abstrakt: Background: Liver cirrhosis, the advanced stage of many chronic liver diseases, is associated with escalated risks of liver-related complications like decompensation and hepatocellular carcinoma (HCC). Morbidity and mortality in cirrhosis patients are linked to portal hypertension, sarcopenia, and hepatocellular carcinoma. Although conventional cirrhosis management centered on treating complications, contemporary approaches prioritize preemptive measures. This study aims to formulate novel blood- and imaging-centric methodologies for monitoring liver cirrhosis patients.
Methods: In this prospective study, 150 liver cirrhosis patients will be enrolled from three Swedish liver clinics. Their conditions will be assessed through extensive blood-based markers and magnetic resonance imaging (MRI). The MRI protocol encompasses body composition profile with Muscle Assement Score, portal flow assessment, magnet resonance elastography, and a abbreviated MRI for HCC screening. Evaluation of lifestyle, muscular strength, physical performance, body composition, and quality of life will be conducted. Additionally, DNA, serum, and plasma biobanking will facilitate future investigations.
Discussion: The anticipated outcomes involve the identification and validation of non-invasive blood- and imaging-oriented biomarkers, enhancing the care paradigm for liver cirrhosis patients. Notably, the temporal evolution of these biomarkers will be crucial for understanding dynamic changes.
Trial Registration: Clinicaltrials.gov, registration identifier NCT05502198. Registered on 16 August 2022. Link: https://classic.
Clinicaltrials: gov/ct2/show/NCT05502198 .
(© 2023. The Author(s).)
Databáze: MEDLINE
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