SEEG electrode shaft affects amplitude and latency of potentials evoked with single pulse electrical stimulation.

Autor: Jedynak M; Aix Marseille Université, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France. Electronic address: maciej.jedynak@protonmail.com., Boyer A; Aix Marseille Université, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France., Mercier M; Aix Marseille Université, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France., Chanteloup-Forêt B; Université Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000 Grenoble, France., Bhattacharjee M; Aix Marseille Université, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France; Université Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000 Grenoble, France., Kahane P; Université Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, 38000 Grenoble, France; Neurology Department, CHU Grenoble Alpes, Grenoble, France., David O; Aix Marseille Université, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France.
Jazyk: angličtina
Zdroj: Journal of neuroscience methods [J Neurosci Methods] 2024 Mar; Vol. 403, pp. 110035. Date of Electronic Publication: 2023 Dec 19.
DOI: 10.1016/j.jneumeth.2023.110035
Abstrakt: Background: Long and thin shaft electrodes are implanted intracerebrally for stereoelectroencephalography (SEEG) in patients with pharmacoresistant focal epilepsies. Two adjacent contacts of one of such electrodes can deliver a train of single pulse electrical stimulations (SPES), and evoked potentials (EPs) are recorded on other contacts. In this study we assess if stimulating and recording on the same shaft, as opposed to different shafts, has an impact on common EP features.
New Method: We leverage the large volume of SEEG data gathered in the F-TRACT database and analyze data from nearly one thousand SEEG implantations in order to verify whether stimulation and recording from the same shaft influence the EP pattern.
Results: We found that when the stimulated and the recording contacts were located on the same shaft, the mean and median amplitudes of an EP are greater, and its mean and median latencies are smaller than when the contacts were located on different shafts. This effect is small (Cohen's d ∼ 0.1), but robust (p-value < 10 -3 ) across the SEEG database.
Comparison With Existing Method(s): Our study is the first one to address this question. Due to the choice of commonly used EP features, our method is congruent with other studies.
Conclusions: The magnitude of the reported effect does not obligate all standard analyses to correct for it, unless they aim at high precision. The source of the effect is not clear. Manufacturers of SEEG electrodes could examine it and potentially minimize the effect in their future products.
Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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