Fracture Risk with Modified FRAX in Men Living with HIV.

Autor:	Castro AP; Federal University of Pará, Brazil. Electronic address: allineperalta@gmail.com., Brito KB; Federal University of Pará, Brazil., Oliva TDR; Federal University of Pará, Brazil., Silva IMS; Federal University of Pará, Brazil., Kato BS; Federal University of Pará, Brazil., Caldeira GAM; Federal University of Pará, Brazil., Santos FM; State University of Pará, Brazil., Libonati RMF; Federal University of Pará, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry [J Clin Densitom] 2024 Jan-Mar; Vol. 27 (1), pp. 101460. Date of Electronic Publication: 2023 Dec 07.
DOI:	10.1016/j.jocd.2023.101460
Abstrakt:	Background: Aging of the HIV-infected population and prolonged use of ARTs, produced metabolic alterations, including increased fracture risk. FRAX is a validated, computer-based clinical fracture risk calculator which estimates 10-year risk of major fracture, and hip fracture. However may underestimate risk in HIV-infected individuals. Several experts recommend considering HIV a cause of secondary osteoporosis. Methodology: Were included 52 men living with HIV, classified as high, moderate and low risk using ABRASSO graphic tool. Results: High risk prevalence found for major fracture and hip fracture were both 2 (4.2 %) using FRAX; while 10 (20.8 %) and 14 (29.2 %) using modified FRAX, respectively. Considering bone densitometry, 5 (12.8 %) were high risk for hip fracture and was noticed an increase in high risk major fracture from 4.2 % with FRAX to 5.1 % with FRAX considering bone densitometry. As for the low risk, 19 (39.6 %) for major fracture and 23 (47.9 %) for hip fracture with FRAX. While low risk modified FRAX were 0 (0 %) for major fracture and 8 (16.7 %) for hip fracture. It was also evidenced an association of high risk for major fracture and hip fracture with modified FRAX using Fisher's exact test [p=0.0273 (bilateral)]. Conclusion: It was concluded is recommended using modified FRAX for people living with HIV for better control and therapeutic decision-making about osteometabolic alterations provocated for the virus and ARTs. Competing Interests: Declaration of Competing Interest None. (Copyright © 2023 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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