Exploring Sorbus torminalis Leaves: Unveiling a Promising Natural Resource for Diverse Chemical and Biological Applications.
Autor: | Ak G; Physiology and Biochemistry Research Laboratory, Department of Biology, Science Faculty, Selcuk University, Konya, 42130, Turkey., Tüfekci EF; Department of Medical Microbiology, Faculty of Medicine, Kastamonu University, Kastamonu, Turkey., Mustafa AM; School of Pharmacy, University of Camerino, Chemistry Interdisciplinary Project (CHIP), via Madonna delle Carceri, 62032, Camerino, Italy., Caprioli G; School of Pharmacy, University of Camerino, Chemistry Interdisciplinary Project (CHIP), via Madonna delle Carceri, 62032, Camerino, Italy., Altunoglu YC; Plantomics Research Laboratory, Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Kastamonu University, Kastamonu, Turkey., Baloglu MC; Plantomics Research Laboratory, Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Kastamonu University, Kastamonu, Turkey.; Sabancı University Nanotechnology Research and Application Center (SUNUM), Sabancı University, Turkey., Cakılcıoglu U; Munzur University, Pertek Sakine Genç Vocational School, Tunceli, Turkey., Polat R; Department of Landscape Architecture, Faculty of Agriculture, Bingol University, Turkey., Darendelioglu E; Department of Molecular Biology and Genetics, Faculty of Sciences, Bingol University, Bingol, Turkey., Zengin G; Physiology and Biochemistry Research Laboratory, Department of Biology, Science Faculty, Selcuk University, Konya, 42130, Turkey. |
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Jazyk: | angličtina |
Zdroj: | Chemistry & biodiversity [Chem Biodivers] 2024 Feb; Vol. 21 (2), pp. e202301596. Date of Electronic Publication: 2024 Feb 06. |
DOI: | 10.1002/cbdv.202301596 |
Abstrakt: | Sorbus torminalis (L.) Crantz has a rich history of versatile applications spanning the fields of medicine and nutrition. It is noteworthy that the decoction obtained from S. torminalis leaves is a traditional treatment method against both diabetes and stomach disorders. Phytochemical profiling determined by HPLC/MS-MS. The effects of the extracts on cell viability were investigated using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method against MDA-MB-231 cell line (human breast adenocarcinoma).The ethanol/water extract contained more concentration of total phenolic (91.41 mg gallic acid (GAE) equivalent /gr) and flavanoid (29.10 mg rutin (RE) equivalent/gr) in the tested extract (p<0.05). Resulting of HPLC analysis, the chemical constituents varied depending on the solvents and chlorogenic acid, hyperoside, isoquercetin, delphindin-3,5-diglucoside, procyanidin B2, epicatechin, neochlorogenic acid, 3,5-dicaffeoylquinic acid were identified in all extracts. Overall, ethanol, n-hexane and ethyl acetate extracts showed the highest inhibition for the tyrosinase enzyme. The effect of leaf extracts of S. torminalis on antimicrobial, biofilm inhibitory, and anticancer activities was examined. Based on outcomes of our study recognize this plant as a critical source of medically active chemicals for feasible phytopharmaceutical and nutraceutical applications, providing the first scientific insight into the detailed biological and chemical profiles of S. torminalis. (© 2023 Wiley-VHCA AG, Zurich, Switzerland.) |
Databáze: | MEDLINE |
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