The evaluation of salivary leucine-rich alpha-2 glycoprotein (LRG) and C-reactive protein (CRP) in humans with periodontal health or periodontal disease.

Autor: Özer E; Department of Periodontology, Faculty of Dentistry, Izmir Katip Celebi University, Izmir, Turkey., Yilmaz HE; Department of Medical Biochemistry, School of Medicine, Izmir Katip Celebi University, Izmir, Turkey.; Izmir Biomedicine Genome Center, Dokuz Eylul University, Izmir, Turkey., Narin F; Department of Medical Biochemistry, School of Medicine, Izmir Katip Celebi University, Izmir, Turkey., Sağlam M; Department of Periodontology, Faculty of Dentistry, Izmir Katip Celebi University, Izmir, Turkey.
Jazyk: angličtina
Zdroj: Journal of periodontal research [J Periodontal Res] 2024 Apr; Vol. 59 (2), pp. 387-394. Date of Electronic Publication: 2023 Dec 21.
DOI: 10.1111/jre.13223
Abstrakt: Objective: The purpose of the present research is to evaluate the salivary levels of leucine-rich alpha-2 glycoprotein (LRG) and C-reactive protein (CRP) in periodontal health and disease (gingivitis and stage III periodontitis) and also to compare the discriminative efficiencies of both biomarkers in periodontal disease.
Background: LRG is a new acute-phase protein whose functions are still being investigated. LRG and CRP are both biomarkers that are increased by inflammation. No clinical study has yet investigated the comparison of the level of LRG and CRP in periodontal health, gingivitis and periodontitis in saliva samples.
Methods: A total of 60 individuals, including 20 periodontally healthy (control group/group C), 20 with gingivitis (group G), and 20 with Stage III periodontitis (group P), who were systemically healthy and non-smokers, participated in this study. Periodontal charts were used for recording clinical periodontal parameters and saliva LRG and CRP levels were measured by ELISA. Analyzing the area under the curve (AUC) was performed by the receiver-operating characteristics curve.
Results: Salivary levels of LRG and CRP were significantly higher in disease groups than in group C (p < .05). Positive statistically significant correlations were observed between both biomarkers and clinical parameters (p < .05). There was also a strong positive correlation between two biomarkers (p < .05). In distinguishing periodontal disease from periodontal health, LRG (AUC = 0.833) and CRP (AUC = 0.826) were found to have similar accuracy (p = .923).
Conclusion: LRG and CRP may be useful and similarly effective biomarkers in the diagnosis of periodontal diseases based on the findings of this study.
(© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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