Epidemiology of feline bartonellosis and molecular characteristics of Bartonella henselae in Bangladesh.

Autor:	Kabir A; Department of Microbiology & Hygiene, Bangladesh Agricultural University, Mymensingh, Bangladesh., Shaker Chouhan C; Department of Medicine, Bangladesh Agricultural University, Mymensingh, Bangladesh., Habib T; Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, Bangladesh., Pratik Siddique M; Department of Microbiology & Hygiene, Bangladesh Agricultural University, Mymensingh, Bangladesh., Nazir KHMNH; Department of Microbiology & Hygiene, Bangladesh Agricultural University, Mymensingh, Bangladesh., Anisur Rahman AKM; Department of Medicine, Bangladesh Agricultural University, Mymensingh, Bangladesh., Amimul Ehsan M; Department of Medicine, Bangladesh Agricultural University, Mymensingh, Bangladesh.
Jazyk:	angličtina
Zdroj:	Saudi journal of biological sciences [Saudi J Biol Sci] 2024 Jan; Vol. 31 (1), pp. 103881. Date of Electronic Publication: 2023 Nov 25.
DOI:	10.1016/j.sjbs.2023.103881
Abstrakt:	Bartonellosis, a neglected vector-borne zoonotic disease transmitted from animals to humans, continues to threaten human and animal health significantly. This study aims to determine the epidemiology of feline bartonellosis and the molecular characteristics of Bartonella spp. in cats. From June 2018 to June 2020, 304 oral swabs were randomly collected from Bangladesh's Dhaka, Mymensingh, and Rajshahi districts. A pre-tested questionnaire was administered to collect data. Oral swabs were subjected to PCR targeting htrA gene to confirm Bartonella spp., which was subsequently validated through sequencing. Risk factors were identified using multivariable logistic regression analysis. The overall prevalence of feline bartonellosis was found to be 15.1 %. The following factors were significantly (p < 0.05) associated with Bartonella infection in risk factor analysis: cats aged ≥ 1 year (OR: 3.23, 95 % CI: 1.38-24.40), local breed cats (OR: 3.37, 95 % CI: 1.05-10.81), cats carrying fleas (OR: 2.33, 95 % CI: 1.93-13.45), antifleacidal drugs inconsistently administered cats (OR: 6.74, 95 % CI: 3.17-14.31), outdoor access cats (OR: 2.54, 95 % CI: 1.16-5.57). Notably, zoonotic B. henselae was confirmed through sequencing, establishing it as the causal agent of cat scratch disease. Phylogenetic analysis showed homology with B. henselae sequences from Brazil, Saint Kitts, and Nevis. We recommend consistent and appropriate flea control measures to curb its spread among Bangladeshi cats. Moreover, limiting outdoor exposure or implementing preventive measures for outdoor cats could reduce the disease burden. The associated human health risk can be decreased by effectively controlling this disease within the cat population. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors.)
Databáze:	MEDLINE
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