Unexplained subfertility: active or conservative management?

Autor:	Ahmad SM; Advanced Reproductive Centre, Faculty of Medicine (ARC), National University of Malaysia (UKM), Kuala Lumpur, Malaysia.; Reproductive Unit, Hospital Tuanku Azizah (HTA), Kuala Lumpur, Malaysia., Mat Jin N; Advanced Reproductive Centre, Faculty of Medicine (ARC), National University of Malaysia (UKM), Kuala Lumpur, Malaysia.; Department of Obstetrics and Gynaecology, Faculty of Medicine, Universiti Teknologi MARA (UiTM), National University of Malaysia (UKM), Selangor, Malaysia., Ahmad MF; Advanced Reproductive Centre, Faculty of Medicine (ARC), National University of Malaysia (UKM), Kuala Lumpur, Malaysia.; Reproductive Unit, Hospital Tuanku Azizah (HTA), Kuala Lumpur, Malaysia., Abdul Karim AK; Advanced Reproductive Centre, Faculty of Medicine (ARC), National University of Malaysia (UKM), Kuala Lumpur, Malaysia.; Department of Obstetrics and Gynaecology, Faculty of Medicine, National University of Malaysia (UKM), Kuala Lumpur, Malaysia., Abu MA; Advanced Reproductive Centre, Faculty of Medicine (ARC), National University of Malaysia (UKM), Kuala Lumpur, Malaysia.; Department of Obstetrics and Gynaecology, Faculty of Medicine, National University of Malaysia (UKM), Kuala Lumpur, Malaysia.
Jazyk:	angličtina
Zdroj:	Hormone molecular biology and clinical investigation [Horm Mol Biol Clin Investig] 2023 Dec 22; Vol. 44 (4), pp. 379-384. Date of Electronic Publication: 2023 Dec 22 (Print Publication: 2023).
DOI:	10.1515/hmbci-2022-0087
Abstrakt:	Objectives: Unexplained subfertility (UEI) describes a couple whose standard subfertility workout consider acceptable but unable to conceived. Methods: This retrospective study was conducted in the Advanced Reproductive Centre, UKM Hospital, Kuala Lumpur, from January 2016 to December 2019. The data of 268 UEI couples were obtained from the clinical database. Women aged 21-45 years old was included and further divided into four groups according to the female partner's age and subfertility duration: group A (age <35 years and subfertility <2 years), group B (age <35 years and subfertility >2 years), group C (age >35 years and subfertility <2 years), and group D (age >35 years and subfertility <2 years). All statistical analyses were performed using SPSS 22.0 for Windows. Results: A total of 255 cases were included in this study. The mean age of the women was 32.9 ± 4.04 years, and the mean subfertility duration was 5.04 ± 2.9 years. A total of 51 (20 %) cases underwent timed sexual intercourse, 147 (57.6 %) cases had intrauterine insemination (IUI), whereas 57 (22.4 %) cases opted for in vitro fertilization (IVF). A total of 204 cases underwent active management (IUI/IVF), which showed a significant difference (p<0.05). Out of eight clinical pregnancies, half of them were from group B. Conclusions: Active management in younger women with a shorter subfertility duration revealed a better pregnancy outcome. Otherwise, individualized treatment should be considered in selecting a suitable treatment plan. (© 2023 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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