| Autor: |
Keserla B; Department of Pharmacy, Annamalai University, Chidambaram, Tamil Nadu, India., Manivasagam GA; Department of Pharmacy, Annamalai University, Chidambaram, Tamil Nadu, India., Das AK; Department of Pharmaceutical Chemistry, Acharya B.M. Reddy College of Pharmacy, Bengaluru, Karnataka, India. |
| Jazyk: |
angličtina |
| Zdroj: |
Natural product research [Nat Prod Res] 2023 Dec 21, pp. 1-8. Date of Electronic Publication: 2023 Dec 21. |
| DOI: |
10.1080/14786419.2023.2283752 |
| Abstrakt: |
This work is the first report dealing with the identification and characterisation of the secondary metabolites of the ethanolic extract of Hydrocharis Laevigata (Humb. & Bonpl. Ex Willd.) Byng & Christenh. The ethanolic extract of H. laevigata was analysed by LCMS& Direct mass spectral analysis which is allowed to identify and Interpreted 6 & 15 compounds. The main constituents were caffeic acid, rosemary acid, Perilic acid, strychnine, hydroxy stearic acid, respectively. The extract further purified by column chromatography 15 fractions was isolated, out of which Perilic acid and strychnine are in high quantities. The structure determination of Perilic acid and strychnine was analysed by FTIR and NMR, respectively. By the molecular docking studies of Perilic acid and strychnine shows active binding energies for antidiabetic activity, respectively. The binding energy was compared with Metformin. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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