Saltwater-Induced Rapid Gelation of Photoredox-Responsive Mucomimetic Hydrogels.

Autor: Zhang Y; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Li R; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Trick TC; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Nosiglia MA; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Palmquist MS; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Wong ML; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Dorsainvil JM; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Tran SL; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Danielson MK; Department of Chemistry, Washington University, St. Louis, MO 63130, USA., Barnes JC; Department of Chemistry, Washington University, St. Louis, MO 63130, USA.
Jazyk: angličtina
Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Mar; Vol. 36 (13), pp. e2307356. Date of Electronic Publication: 2023 Dec 28.
DOI: 10.1002/adma.202307356
Abstrakt: Shear-thinning hydrogels represent an important class of injectable soft materials that are often used in a wide range of biomedical applications. Creation of new shear-thinning materials often requires that factors such as viscosity, injection rate/force, and needle gauge be evaluated to achieve efficient delivery, while simultaneously protecting potentially sensitive cargo. Here, a new approach to establishing shear-thinning hydrogels is reported where a host-guest cross-linked network initially remains soluble in deionized water but is kinetically trapped as a viscous hydrogel once exposed to saltwater. The shear-thinning properties of the hydrogel is then "switched on" in response to heating or exposure to visible light. These hydrogels consist of polynorbornene-based bottlebrush copolymers with porphyrin- and oligoviologen-containing side chains that are cross-linked through the reversible formation of β-cyclodextrin-adamantane inclusion complexes. The resultant viscous hydrogels display broad adhesive properties across polar and nonpolar substrates, mimicking that of natural mucous and thus making it easier to distribute onto a wide range of surfaces. Additional control over the hydrogel's mechanical properties (storage/loss moduli) and performance (adhesion) is achieved post-injection using a low-energy (blue light) photoinduced electron-transfer process. This work envisions these injectable copolymers and multimodal hydrogels can serve as versatile next-generation biomaterials capable of light-based mechanical manipulation post-injection.
(© 2023 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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