| Autor: |
Kaneda Y; Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu, Japan., Kanemura N; Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu, Japan., Nakamura N; Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu, Japan., Ikoma Y; Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu, Japan., Yamaguchi K; Department of Hematology, Gifu Municipal Hospital, Gifu, Japan., Takada E; Department of Hematology, Gifu-Seino Medical Center, Gihoku Kosei Hospital, Gifu, Japan., Shibata Y; Department of Hematology, Gifu Municipal Hospital, Gifu, Japan., Lee S; Department of Hematology, Matsunami General Hospital, Gifu, Japan., Fujita K; Department of Hematology, Matsunami General Hospital, Gifu, Japan., Morishita T; Department of Hematology, Matsunami General Hospital, Gifu, Japan., Matsumoto T; Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu, Japan., Nakamura H; Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu, Japan., Kitagawa J; Department of Hematology, Gifu Municipal Hospital, Gifu, Japan., Kasahara S; Department of Hematology, Gifu Municipal Hospital, Gifu, Japan., Hara T; Department of Hematology, Matsunami General Hospital, Gifu, Japan., Tsurumi H; Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu, Japan.; Department of Hematology, Matsunami General Hospital, Gifu, Japan., Shimizu M; Department of Hematology and Infectious Disease, Gifu University Hospital, Gifu, Japan. |
| Abstrakt: |
Predicting prognosis is crucial in older patients with diffuse large B-cell lymphoma (DLBCL). This study evaluated the prognostic impact of the controlling nutritional status (CONUT) score, a simple nutritional index, for older DLBCL patients (≥65 years of age) treated with R-CHOP-like regimens in a retrospective, cohort study including 203 patients. The CONUT score was an independent prognostic factor for overall survival (hazard ratio 1.11, 95% confidence interval (CI) 1.01-1.21, p = 0.032) in a multivariable Cox proportional hazards model. On receiver-operating characteristic analysis, the optimal cutoff value was 3. The CONUT score (≥3 or <3) effectively stratified older DLBCL patients, regardless of the International Prognostic Index ( p = 0.71 for interaction). Further, the CONUT score independently affected initial dose intensity (odds ratio 0.84, 95% CI 0.73-0.95, p = 0.008), likely reflecting the patients' status at diagnosis and affecting dose adjustments. In conclusion, the CONUT score is associated with a poorer prognosis in older DLBCL patients. |
