Successful Prediction of Fetal Exposure to Dual BCRP/P-gp Drug Substrates Using the Efflux Ratio-Relative Expression Factor Approach and PBPK M&S.
Autor: | Balhara A; Department of Pharmaceutics, University of Washington, Seattle, Washington, USA., Yin M; Department of Pharmaceutics, University of Washington, Seattle, Washington, USA., Unadkat JD; Department of Pharmaceutics, University of Washington, Seattle, Washington, USA. |
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Jazyk: | angličtina |
Zdroj: | Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2024 May; Vol. 115 (5), pp. 1044-1053. Date of Electronic Publication: 2024 Jan 08. |
DOI: | 10.1002/cpt.3157 |
Abstrakt: | To inform fetal drug safety, it is important to determine or predict fetal drug exposure throughout pregnancy. The former is not possible in the first or second trimester. In contrast, at the time of birth, fetal drug exposure, relative to maternal exposure, can be estimated as K (© 2023 The Authors. Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.) |
Databáze: | MEDLINE |
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