Embracing ethical research: Implementing the 3R principles into fracture healing research for sustainable scientific progress.

Autor: Anup A; Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA., Dieterich S; Institute of Orthopaedic Research and Biomechanics, University Medical Center Ulm, Ulm, Germany., Oreffo ROC; Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Dailey HL; Departments of Orthopaedic Surgery and Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Lang A; Department of Mechanical Engineering and Mechanics, Lehigh University, Bethlehem, Pennsylvania, USA., Haffner-Luntzer M; Institute of Orthopaedic Research and Biomechanics, University Medical Center Ulm, Ulm, Germany., Hixon KR; Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.; Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Jazyk: angličtina
Zdroj: Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2024 Mar; Vol. 42 (3), pp. 568-577. Date of Electronic Publication: 2023 Dec 20.
DOI: 10.1002/jor.25741
Abstrakt: As scientific advancements continue to reshape the world, it becomes increasingly crucial to uphold ethical standards and minimize the potentially adverse impact of research activities. In this context, the implementation of the 3R principles-Replacement, Reduction, and Refinement-has emerged as a prominent framework for promoting ethical research practices in the use of animals. This article aims to explore recent advances in integrating the 3R principles into fracture healing research, highlighting their potential to enhance animal welfare, scientific validity, and societal trust. The review focuses on in vitro, in silico, ex vivo, and refined in vivo methods, which have the potential to replace, reduce, and refine animal experiments in musculoskeletal, bone, and fracture healing research. Here, we review material that was presented at the workshop "Implementing 3R Principles into Fracture Healing Research" at the 2023 Orthopedic Research Society (ORS) Annual Meeting in Dallas, Texas.
(© 2023 Orthopaedic Research Society.)
Databáze: MEDLINE
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