The Concise Guide to PHARMACOLOGY 2023/24: Transporters.

Autor: Alexander SPH; School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK., Fabbro D; PIQUR Therapeutics, Basel, 4057, Switzerland., Kelly E; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK., Mathie AA; School of Allied Health Sciences, University of Suffolk, Ipswich, IP4 1QJ, UK., Peters JA; Neuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK., Veale EL; School of Allied Health Sciences, University of Suffolk, Ipswich, IP4 1QJ, UK., Armstrong JF; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK., Faccenda E; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK., Harding SD; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK., Davies JA; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK., Amarosi L; University of Salento, Lecce, Italy., Anderson CMH; Newcastle University, Newcastle upon Tyne, UK., Beart PM; Florey Institute of Neuroscience and Mental Health, Melbourne, Australia., Broer S; Australian National University, Canberra, Australia., Dawson PA; Emory University, Atlanta, USA., Gyimesi G; University of Bern, Bern, Switzerland., Hagenbuch B; University of Kansas, Kansas City, USA., Hammond JR; University of Alberta, Edmonton, Canada., Hancox JC; University of Bristol, Bristol, UK., Hershfinkel M; Ben-Gurion University of the Negev, Beer Sheva, Israel., Inui KI; Kyoto Pharmaceutical University, Kyoto, Japan., Kanai Y; Osaka University, Osaka, Japan., Kemp S; Amsterdam University, Amsterdam, The Netherlands., Kunji ERS; University of Cambridge, Cambridge, UK., Stewart G; University College Dublin, Dublin, Ireland., Tavoulari S; University of Cambridge, Cambridge, UK., Thwaites DT; Newcastle University, Newcastle upon Tyne, UK., Verri T; University of Salento, Lecce, Italy.
Jazyk: angličtina
Zdroj: British journal of pharmacology [Br J Pharmacol] 2023 Oct; Vol. 180 Suppl 2, pp. S374-S469.
DOI: 10.1111/bph.16182
Abstrakt: The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16182. Transporters are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors and enzymes. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
(© 2023 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society.)
Databáze: MEDLINE
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