Engineered stem cell-based strategy: A new paradigm of next-generation stem cell product in regenerative medicine.

Autor: Han H; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China., Chen BT; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China., Liu Y; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China., Wang Y; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China., Xing L; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China; College of Pharmacy, Yanbian University, Yanji 133002, China., Wang H; Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China., Zhou TJ; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China. Electronic address: zhoutj1993@163.com., Jiang HL; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China; College of Pharmacy, Yanbian University, Yanji 133002, China. Electronic address: jianghulin3@163.com.
Jazyk: angličtina
Zdroj: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2024 Jan; Vol. 365, pp. 981-1003. Date of Electronic Publication: 2023 Dec 21.
DOI: 10.1016/j.jconrel.2023.12.024
Abstrakt: Stem cells have garnered significant attention in regenerative medicine owing to their abilities of multi-directional differentiation and self-renewal. Despite these encouraging results, the market for stem cell products yields limited, which is largely due to the challenges faced to the safety and viability of stem cells in vivo. Besides, the fate of cells re-infusion into the body unknown is also a major obstacle to stem cell therapy. Actually, both the functional protection and the fate tracking of stem cells are essential in tissue homeostasis, repair, and regeneration. Recent studies have utilized cell engineering techniques to modify stem cells for enhancing their treatment efficiency or imparting them with novel biological capabilities, in which advances demonstrate the immense potential of engineered cell therapy. In this review, we proposed that the "engineered stem cells" are expected to represent the next generation of stem cell therapies and reviewed recent progress in this area. We also discussed potential applications of engineered stem cells and highlighted the most common challenges that must be addressed. Overall, this review has important guiding significance for the future design of new paradigms of stem cell products to improve their therapeutic efficacy.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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