Epilepsy is more than a simple seizure disorder: Parallels between human and canine cognitive and behavioural comorbidities.

Autor: Peek SI; Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Germany., Meller S; Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Germany., Twele F; Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Germany., Packer RMA; The Royal Veterinary College, Hatfield, Hertfordshire, UK., Volk HA; Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Germany. Electronic address: Holger.Volk@tiho-hannover.de.
Jazyk: angličtina
Zdroj: Veterinary journal (London, England : 1997) [Vet J] 2024 Feb; Vol. 303, pp. 106060. Date of Electronic Publication: 2023 Dec 19.
DOI: 10.1016/j.tvjl.2023.106060
Abstrakt: Psychiatric and cognitive comorbidities have been known to play a major role in human epilepsy for a long time. People with epilepsy (PWE) frequently express signs of varying psychiatric and cognitive disorders affecting their quality and quantity of life (QoL/QaoL). Over the last few years, research on behavioural comorbidities and their effect on the underlying disease have been performed in canine epilepsy. The following article reviews manifestations of comorbidities in canine epilepsy with an emphasis on patterns of clinical signs and their effects on QoL and QaoL. Cognitive and behavioural alterations in epileptic dogs are mainly represented by fear-/anxiety related behaviour and cognitive impairment (CI). Reduced trainability and altered reactions to daily situations are common results of comorbid changes posing obstacles in everyday life of owners and their dog. In addition, clinical signs similar to attention deficit hyperactivity disorder (ADHD) in humans have been reported. Canine attention-deficit-hyperactivity-disorder-like (c-ADHD-like) behaviour should, however, be evaluated critically, as there are no official criteria for diagnosis of ADHD or ADHD-like behaviour in dogs, and some of the reported signs of c-ADHD-like behaviour could be confused with anxiety-associated behaviour. Many intrinsic and extrinsic factors could potentially influence the development of behavioural and cognitive comorbidities in canine epilepsy. In particular, seizure frequency/severity, signalment and factors concerning disease management, such as pharmacotherapy and nutrition, are closely linked with the presence of the aforementioned comorbid disorders. Further studies of behavioural alterations in epileptic dogs are needed to comprehend the complexity of clinical signs and their multifactorial origin.
Competing Interests: Declaration of Competing Interest None of the authors has any financial or personal relationships that could inappropriately influence or bias the content of the paper.
(Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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