Nutrient inputs and social metabolic control of T cell fate.
| Autor: | Bacigalupa ZA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Landis MD; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Rathmell JC; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: jeff.rathmell@vumc.org. |
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| Jazyk: | angličtina |
| Zdroj: | Cell metabolism [Cell Metab] 2024 Jan 02; Vol. 36 (1), pp. 10-20. Date of Electronic Publication: 2023 Dec 19. |
| DOI: | 10.1016/j.cmet.2023.12.009 |
| Abstrakt: | Cells in multicellular organisms experience diverse neighbors, signals, and evolving physical environments that drive functional and metabolic demands. To maintain proper development and homeostasis while avoiding inappropriate cell proliferation or death, individual cells interact with their neighbors via "social" cues to share and partition available nutrients. Metabolic signals also contribute to cell fate by providing biochemical links between cell-extrinsic signals and available resources. In addition to metabolic checkpoints that sense nutrients and directly supply molecular intermediates for biosynthetic pathways, many metabolites directly signal or provide the basis for post-translational modifications of target proteins and chromatin. In this review, we survey the landscape of T cell nutrient sensing and metabolic signaling that supports proper immunity while avoiding immunodeficiency or autoimmunity. The integration of cell-extrinsic microenvironmental cues with cell-intrinsic metabolic signaling provides a social metabolic control model to integrate cell signaling, metabolism, and fate. Competing Interests: Declaration of interests J.C.R. consults as a scientific advisory board member of Sitryx Therapeutics. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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