Methodological Approach to Identify and Expand the Volume of Antimicrobial Resistance (AMR) Data in the Human Health Sector in Low- and Middle-Income Countries in Asia: Implications for Local and Regional AMR Surveillance Systems Strengthening.

Autor:	Joh HS; International Vaccine Institute, Seoul, Republic of Korea., Yeats C; Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Oxford, United Kingdom., Shaw A; Public Health Surveillance Group, LLC, Princeton, New Jersey, USA., Poudyal N; International Vaccine Institute, Seoul, Republic of Korea., Gallagher P; Public Health Surveillance Group, LLC, Princeton, New Jersey, USA., Kim JH; International Vaccine Institute, Seoul, Republic of Korea., Shaikh A; Public Health Surveillance Group, LLC, Princeton, New Jersey, USA., Seo HJ; International Vaccine Institute, Seoul, Republic of Korea., Chi KK; International Vaccine Institute, Seoul, Republic of Korea., Prifti K; International Vaccine Institute, Seoul, Republic of Korea., Cho A; International Vaccine Institute, Seoul, Republic of Korea., Sujan MJ; International Vaccine Institute, Seoul, Republic of Korea., Eraly E; International Vaccine Institute, Seoul, Republic of Korea., Pham KD; International Vaccine Institute, Seoul, Republic of Korea., Shrestha S; International Vaccine Institute, Seoul, Republic of Korea., Aboushady AT; International Vaccine Institute, Seoul, Republic of Korea.; Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Pak G; International Vaccine Institute, Seoul, Republic of Korea., Jang G; International Vaccine Institute, Seoul, Republic of Korea., Park EL; International Vaccine Institute, Seoul, Republic of Korea., Seo HW; International Vaccine Institute, Seoul, Republic of Korea., Abudahab K; Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Oxford, United Kingdom., Taylor BEW; Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Oxford, United Kingdom., Clark A; Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Dolabella B; Public Health Surveillance Group, LLC, Princeton, New Jersey, USA., Yoon H; International Vaccine Institute, Seoul, Republic of Korea., Han J; International Vaccine Institute, Seoul, Republic of Korea., Kwon SY; International Vaccine Institute, Seoul, Republic of Korea., Marks F; International Vaccine Institute, Seoul, Republic of Korea.; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.; Heidelberg Institute of Global Health, University of Heidelberg, Heidelberg, Germany.; Madagascar Institute for Vaccine Research, University of Antananarivo, Antananarivo, Madagascar., Stelling J; Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Aanensen DM; Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Oxford, United Kingdom., MacWright WR; Public Health Surveillance Group, LLC, Princeton, New Jersey, USA., Holm M; International Vaccine Institute, Seoul, Republic of Korea.
Jazyk:	angličtina
Zdroj:	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2023 Dec 20; Vol. 77 (Suppl 7), pp. S507-S518.
DOI:	10.1093/cid/ciad634
Abstrakt:	Antimicrobial resistance (AMR) is a multifaceted global health problem disproportionately affecting low- and middle-income countries (LMICs). The Capturing data on Antimicrobial resistance Patterns and Trends in Use in Regions of Asia (CAPTURA) project was tasked to expand the volume of AMR and antimicrobial use data in Asia. The CAPTURA project used 2 data-collection streams: facility data and project metadata. Project metadata constituted information collected to map out data sources and assess data quality, while facility data referred to the retrospective data collected from healthcare facilities. A down-selection process, labelled "the funnel approach" by the project, was adopted to use the project metadata in prioritizing and selecting laboratories for retrospective AMR data collection. Moreover, the metadata served as a guide for understanding the AMR data once they were collected. The findings from CAPTURA's metadata add to the current discourse on the limitation of AMR data in LMICs. There is generally a low volume of AMR data generated as there is a lack of microbiology laboratories with sufficient antimicrobial susceptibility testing capacity. Many laboratories in Asia are still capturing data on paper, resulting in scattered or unused data not readily accessible or shareable for analyses. There is also a lack of clinical and epidemiological data captured, impeding interpretation and in-depth understanding of the AMR data. CAPTURA's experience in Asia suggests that there is a wide spectrum of capacity and capability of microbiology laboratories within a country and region. As local AMR surveillance is a crucial instrument to inform context-specific measures to combat AMR, it is important to understand and assess current capacity-building needs while implementing activities to enhance surveillance systems. Competing Interests: Potential conflicts of interest. A. Clark reports receiving funds for their institution from the CAPTURA grant. A. T. A. reports being an employee of Brigham and Women's Hospital since September 2022 and a consultant since 2021 and working as a consultant for the CAPTURA project from September 2021 to March 2022. A. S. reports receiving compensation from the Public Health Surveillance Group. W. M. reports receiving financial support from the International Vaccine Group, UKAID, and a subgrant for CAPTURA work. B. D. reports receiving compensation from the Public Health Surveillance Group. D. M. A. reports receiving financial support from the National Institute for Health and Care Research (NIHR) Global Health Research Unit on genomic surveillance of AMR and the Centre for Genomic Pathogen Surveillance. J. S. reports a subcontract for salary support and travel from the International Vaccine Institute. E. E. reports being a consultant with the International Vaccine Institute since April 2021 and staff and consulting funds from the WHO WPRO, ABD, FHI, and UNICEF. P. G. reports receiving compensation from the Public Health Surveillance Group. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze:	MEDLINE
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