Understanding the value of brain donation for research to donors, next-of-kin and clinicians: A systematic review.

Autor: Griffin CP; College of Health, Medicine and Wellbeing University of Newcastle, Tamworth, NSW, Australia.; Hunter Medical Research Institute, Newcastle, NSW, Australia., Bowen JR; College of Health, Medicine and Wellbeing University of Newcastle, Tamworth, NSW, Australia.; Hunter Medical Research Institute, Newcastle, NSW, Australia., Walker MM; College of Health, Medicine and Wellbeing University of Newcastle, Tamworth, NSW, Australia., Lynam J; College of Health, Medicine and Wellbeing University of Newcastle, Tamworth, NSW, Australia.; Hunter Medical Research Institute, Newcastle, NSW, Australia.; Department of Medical Oncology, Calvary Mater, Newcastle, NSW, Australia., Paul CL; College of Health, Medicine and Wellbeing University of Newcastle, Tamworth, NSW, Australia.; Hunter Medical Research Institute, Newcastle, NSW, Australia.; Priority Research Centre Cancer Research, Innovation and Translation, University of Newcastle, Callaghan, Australia.; Priority Research Centre Health Behaviour, University of Newcastle, Callaghan, Australia.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Dec 20; Vol. 18 (12), pp. e0295438. Date of Electronic Publication: 2023 Dec 20 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0295438
Abstrakt: Purpose: Post-mortem brain donation affords the opportunity to characterise disease by exploring global neuropathological changes. Such opportunities are essential to progress knowledge of CNS tumours such as Glioblastoma. A comprehensive understanding of the experience of consenting to brain donation is crucial to maximising consent rates while providing patient-centred care. This review aimed to synthesise the reported facilitators and barriers according to potential donors, next-of-kin (NOK) and clinician respondents.
Design: Database searches included Embase, Medline, PsycINFO, Psychology and Behavioural Science and Scopus. Search terms focused on motivations, attitudes and psychosocial experiences of brain donation. Exclusions included organ transplantation and brain death. All studies were assessed for quality and validity using tools from the Joanna Briggs Institute. To determine perceptions of benefit and harm, a method guided by the thematic analysis of Braun and Clarke was employed to reflexively assess and identify common themes and experiences.
Results: 40 studies (15 qualitative, 25 quantitative) were included involving participants with paediatric cancer, neurodegenerative and psychological diseases. Perceptions of benefit included benefit to future generations, aiding scientific research, avoidance of waste, improved treatments and the belief that donation will bring consolation or aid in the grieving process. Perceptions of harm included a perceived conflict with religious beliefs, disfigurement to the donor, emotional distress at the time of autopsy and discord or objections within the family.
Conclusion: Brain donation can afford a sense of purpose, meaning and empowerment for donors and their loved ones. Careful strategies are required to mitigate or reduce potential harms during the consent process.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Griffin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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