The Brazilian Toxoplasma gondii strain BRI caused greater inflammation and impairment in anxiogenic behavior in mice, which was reverted by rosuvastatin treatment.

Autor: Evangelista FF; Department of Health Sciences, State University of Maringá (UEM), Maringá, PR, Brazil. fer.evangelista@hotmail.com., de Laet Sant'Ana P; Department of Health Sciences, State University of Maringá (UEM), Maringá, PR, Brazil., Ferreira WC; Department of Health Sciences, Unicesumar, Maringá, PR, Brazil., Ferreira TA; State University of Maringá (UEM), Maringá, PR, Brazil., Dos Santos ML; State University of Maringá (UEM), Maringá, PR, Brazil., de Souza AH; Pharmaceutical Sciences Program, State University of Maringá (UEM), Maringá, PR, Brazil., de Andrade FAL; State University of Maringá (UEM), Maringá, PR, Brazil., da Silva DA; Department of Preventive Veterinary Medicine, State University of Londrina (UEL), Londrina, PR, Brazil., de Barros LD; Department of Preventive Veterinary Medicine, State University of Londrina (UEL), Londrina, PR, Brazil., Colli CM; Federal University of Grande Dourados (UFGD), Dourados, MS, Brazil., Nogueira-Melo GA; Department of Clinical Analysis and Biomedicine, State University of Maringá (UEM), Maringá, PR, Brazil., Costa IN; Department of Pathological Sciences, State University of Londrina (UEL), Londrina, PR, Brazil., Falavigna-Guilherme AL; Department of Health Sciences, State University of Maringá (UEM), Maringá, PR, Brazil.
Jazyk: angličtina
Zdroj: Parasitology research [Parasitol Res] 2023 Dec 20; Vol. 123 (1), pp. 64. Date of Electronic Publication: 2023 Dec 20.
DOI: 10.1007/s00436-023-08038-4
Abstrakt: This study aimed to investigate the effect of rosuvastatin treatment on anxiety-related behavior and short- and long-term memory impairment in mice infected with acute RH and BRI strains of Toxoplasma gondii. Balb/C mice were infected intraperitoneally and after 2 h, oral treatment with rosuvastatin (40 mg/kg/day) was initiated for 4 days. Behaviors related to anxiety and locomotion were evaluated in the open field (OF), and short- and long-term memory through the novel object recognition test (NOR). At the end of the experiments, peritoneal fluid, brain, liver, and lung were collected for T. gondii DNA quantification and histopathological analysis. Infection with BRI strain reduced the dwell time and central locomotion in the OF (p < 0.05), indicating anxiogenic type behavior, while treatment with rosuvastatin reversed this response (p < 0.05). RH strain infection did not alter any behavior in the OF (p > 0.05) and both strains impaired short- and long-term memory (NOR test), but with no significant treatment effect (p > 0.05). The BRI strain was shown to be more damaging in relation to anxiogenic type behavior when compared to the RH strain (p < 0.05), whereas rosuvastatin reduced this damaging effect in BRI. The treatment reduced the parasite load in the peritoneal lavage, liver, and lung of animals infected with both acute strains; however, it significantly (p < 0.05) attenuated the inflammatory process only in BRI-infected and treated animals, showing that non-archetypal genotypes are more damaging in rodents. This suggests that rosuvastatin may be a drug with great therapeutic potential against T. gondii mainly to reduce damage from virulent strains.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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