Sleep dysfunction associated with worse chemotherapy-induced peripheral neurotoxicity functional outcomes.

Autor: Mahfouz FM; Brain and Mind Centre, The University of Sydney, Camperdown, NSW, 2050, Australia., Li T; Brain and Mind Centre, The University of Sydney, Camperdown, NSW, 2050, Australia., Joda M; Brain and Mind Centre, The University of Sydney, Camperdown, NSW, 2050, Australia., Harrison M; Chris O'Brien Lifehouse, Camperdown, NSW, 2050, Australia., Horvath LG; Chris O'Brien Lifehouse, Camperdown, NSW, 2050, Australia.; Sydney Medical School, The University of Sydney, Camperdown, NSW, 2050, Australia.; Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia., Grimison P; Chris O'Brien Lifehouse, Camperdown, NSW, 2050, Australia.; Sydney Medical School, The University of Sydney, Camperdown, NSW, 2050, Australia., King T; Cancer Nursing Research Unit, The University of Sydney, Camperdown, NSW, 2050, Australia.; Institute of Haematology, Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia., Marx G; Sydney Adventist Hospital, Wahroonga, NSW, 2076, Australia., Goldstein D; Prince of Wales Clinical School, Faculty of Medicine & Health, UNSW Sydney, Randwick, NSW, 2031, Australia.; Department of Medical Oncology, Prince of Wales Hospital, Randwick, NSW, 2031, Australia., Park SB; Brain and Mind Centre, The University of Sydney, Camperdown, NSW, 2050, Australia. susanna.park@sydney.edu.au.
Jazyk: angličtina
Zdroj: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2023 Dec 20; Vol. 32 (1), pp. 46. Date of Electronic Publication: 2023 Dec 20.
DOI: 10.1007/s00520-023-08245-w
Abstrakt: Purpose: Sleep problems are commonly reported by cancer survivors; however, knowledge of the impact of chemotherapy-induced peripheral neurotoxicity (CIPN) on sleep quality remains limited. In this study, we explored the impact of CIPN on sleep quality, as well as identified clinical characteristics associated with poor sleep quality.
Methods: Participants were assessed cross-sectionally post-neurotoxic chemotherapy. CIPN severity was graded using a range of questionnaires that assessed CIPN severity and quality of life, as well as neurological grading scales. Sleep quality was assessed using a self-rated questionnaire (Pittsburgh Sleep Quality Index, PSQI). Participants with poor sleep quality were further grouped according to whether sleep impairment was due to CIPN or other factors.
Results: Among 77 participants who reported CIPN, 75% (n = 58) reported poor sleep quality. Of those, 41% (n = 24) reported CIPN as contributing to sleep impairment, while 59% (n = 34) reported other causes. Participants with CIPN-induced sleep impairments had higher CIPN severity across all outcome measures, as well as greater neuropathic pain (all p < 0.05). Furthermore, participants with CIPN-induced sleep impairments reported worse impact of neuropathy on physical and social functioning, as well as emotional well-being (all p < 0.05).
Conclusions: Participants with CIPN-induced poor sleep quality reported worse scores across all CIPN severity measures. This emphasises the negative impacts of CIPN symptoms on quality of life of chemotherapy-treated patients and highlights the importance of sleep quality assessment in cancer survivors.
(© 2023. The Author(s).)
Databáze: MEDLINE
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